Leukocyte surface antigen CD53 is aprotein that in humans is encoded by theCD53gene.[5][6]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein.[6]
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Gonzalez ME, Pardo-Manuel de Villena F, Fernandez-Ruiz E, et al. (1994). "The human CD53 gene, coding for a four transmembrane domain protein, maps to chromosomal region 1p13".Genomics.18 (3):725–728.doi:10.1016/S0888-7543(05)80385-4.hdl:10261/72861.PMID8307585.
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Virtaneva KI, Angelisová P, Baumruker T, et al. (1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes".Immunogenetics.37 (6):461–465.doi:10.1007/BF00222471.hdl:10138/157839.PMID8436422.S2CID8899453.
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