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CD53

From Wikipedia, the free encyclopedia
Mammalian protein found in humans

CD53
Identifiers
AliasesCD53, MOX44, TSPAN25, CD53 molecule
External IDsOMIM:151525;MGI:88341;HomoloGene:20152;GeneCards:CD53;OMA:CD53 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CD53
Genomic location for CD53
Band1p13.3Start110,871,188bp[1]
End110,899,922bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for CD53
Genomic location for CD53
Band3 F2.3|3 46.53 cMStart106,667,237bp[2]
End106,697,465bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood

  • granulocyte

  • mononuclear cell

  • monocyte

  • spleen

  • appendix

  • lymph node

  • bone marrow

  • bone marrow cells

  • epithelium of nasopharynx
Top expressed in
  • granulocyte

  • mesenteric lymph nodes

  • spleen

  • stroma of bone marrow

  • tibiofemoral joint

  • blood

  • right lung lobe

  • thymus

  • calvaria

  • subcutaneous adipose tissue
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

963

12508

Ensembl

ENSG00000143119

ENSMUSG00000040747

UniProt

P19397

Q61451

RefSeq (mRNA)

NM_000560
NM_001040033
NM_001320638

NM_007651

RefSeq (protein)

NP_000551
NP_001035122
NP_001307567

NP_031677

Location (UCSC)Chr 1: 110.87 – 110.9 MbChr 3: 106.67 – 106.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leukocyte surface antigen CD53 is aprotein that in humans is encoded by theCD53gene.[5][6]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein.[6]

See also

[edit]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000143119Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000040747Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Korinek V, Horejsi V (Jul 1993). "Genomic structure of the human CD53 gene".Immunogenetics.38 (4):272–279.doi:10.1007/BF00188803.PMID 8319976.S2CID 6683727.
  6. ^ab"Entrez Gene: CD53 CD53 molecule".

Further reading

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External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

1–50
51–100
101–150
151–200
201–250
251–300
301–350
Arrestin
Membrane-spanning 4A
Myelin
Pulmonary surfactant
Tetraspanin
Other/ungrouped


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