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Integrin alpha 2

From Wikipedia, the free encyclopedia
(Redirected fromCD49b)

Mammalian protein found in Homo sapiens
ITGA2
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

1AOX,1DZI,1V7P,4BJ3

Identifiers
AliasesITGA2, BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, integrin subunit alpha 2
External IDsOMIM:192974;MGI:96600;HomoloGene:1662;GeneCards:ITGA2;OMA:ITGA2 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for ITGA2
Genomic location for ITGA2
Band5q11.2Start52,989,340bp[1]
End53,094,779bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for ITGA2
Genomic location for ITGA2
Band13 D2.2|13 64.61 cMStart114,969,617bp[2]
End115,068,636bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • epithelium of nasopharynx

  • bronchial epithelial cell

  • islet of Langerhans

  • visceral pleura

  • skin of thigh

  • skin of hip

  • gingival epithelium

  • seminal vesicula

  • vulva
Top expressed in
  • gastrula

  • cumulus cell

  • lumbar spinal ganglion

  • molar

  • blood

  • trigeminal ganglion

  • Paneth cell

  • decidua

  • left lung lobe

  • stellate reticulum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3673

16398

Ensembl

ENSG00000164171

ENSMUSG00000015533

UniProt

P17301

Q62469

RefSeq (mRNA)

NM_002203

NM_008396

RefSeq (protein)

NP_002194

NP_032422

Location (UCSC)Chr 5: 52.99 – 53.09 MbChr 13: 114.97 – 115.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integrin alpha-2, orCD49b (cluster of differentiation 49b), is aprotein which in humans is encoded by theCD49bgene.

The CD49b protein is anintegrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membraneglycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types includingT cells (theNKT cells),NK cells,fibroblasts andplatelets. Integrins are involved incell adhesion and also participate in cell-surface-mediated signalling.[5]

Expression of CD49b in conjunction withLAG-3 has been used to identifytype 1 regulatory (Tr1) cells.[6]

The DX5monoclonal antibody recognizes mouse CD49b.[7]

Interactions

[edit]

CD49b has been shown tointeract withMMP1.[8][9]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000164171Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000015533Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"Entrez Gene: ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)".
  6. ^Gagliani N, Magnani CF, Huber S, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A (2013-06-01). "Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells".Nature Medicine.19 (6):739–746.doi:10.1038/nm.3179.ISSN 1546-170X.PMID 23624599.S2CID 21305032.
  7. ^Arase H, Saito T, Phillips JH, Lanier LL (August 2001)."Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)".Journal of Immunology.167 (3):1141–4.doi:10.4049/jimmunol.167.3.1141.PMID 11466327.
  8. ^Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA (Aug 2001)."Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction".J. Biol. Chem.276 (31):29375–81.doi:10.1074/jbc.M102217200.PMID 11359774.
  9. ^Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC (Aug 2001)."Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen".J. Biol. Chem.276 (31):29368–74.doi:10.1074/jbc.M104179200.PMID 11359786.

External links

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Further reading

[edit]

External links

[edit]
PDB gallery
  • 1aox: I DOMAIN FROM INTEGRIN ALPHA2-BETA1
    1aox: I DOMAIN FROM INTEGRIN ALPHA2-BETA1
  • 1dzi: INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX
    1dzi: INTEGRIN ALPHA2 I DOMAIN / COLLAGEN COMPLEX
  • 1v7p: Structure of EMS16-alpha2-I domain complex
    1v7p: Structure of EMS16-alpha2-I domain complex
1–50
51–100
101–150
151–200
201–250
251–300
301–350
Alpha
Beta
Dimers
Cytoadhesin receptor:
Fibrinogen receptor:
Fibronectin receptor:
Leukocyte-adhesion receptor:
Very late antigen receptor:
Vitronectin receptor:


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