Integrin alpha-2, orCD49b (cluster of differentiation 49b), is aprotein which in humans is encoded by theCD49bgene.
The CD49b protein is anintegrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membraneglycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types includingT cells (theNKT cells),NK cells,fibroblasts andplatelets. Integrins are involved incell adhesion and also participate in cell-surface-mediated signalling.[5]
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