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CD302

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From Wikipedia, the free encyclopedia

Protein-coding gene in humans

CD302

Identifiers

Aliases

CD302, BIMLEC, CLEC13A, DCL-1, DCL1, CD302 molecule

External IDs

OMIM:612246;MGI:1913455;HomoloGene:8919;GeneCards:CD302;OMA:CD302 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q24.2	Start	159,768,628bp^[1]
Band	2q24.2	End	159,798,255bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 C1.1	Start	60,082,337bp^[2]
Band	2\|2 C1.1	End	60,114,832bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

lower lobe of lung

monocyte

right lung

liver

synovial joint

trabecular bone

synovial membrane

right lobe of liver

Achilles tendon

superficial temporal artery

Top expressed in

left lobe of liver

white adipose tissue

calvaria

stroma of bone marrow

right kidney

tunica adventitia of aorta

right lung lobe

mesenteric lymph nodes

carotid body

skin of external ear

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	carbohydrate binding transmembrane signaling receptor activity
Cellular component	filopodium cytoplasm integral component of membrane microvillus cell projection cell cortex membrane integral component of plasma membrane
Biological process	phagocytosis signal transduction
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


9936


66205

Ensembl


ENSG00000241399


ENSMUSG00000060703

UniProt


Q8IX05


Q9DCG2

RefSeq (mRNA)


NM_014880 NM_001198763 NM_001198764


NM_001290660 NM_025422

RefSeq (protein)


NP_001185692 NP_001185693 NP_055695


NP_001277589 NP_079698

Location (UCSC)

Chr 2: 159.77 – 159.8 Mb

Chr 2: 60.08 – 60.11 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

TheCD302 antigen also known asC-type lectin domain family 13 member A is aprotein that in humans is encoded by theCD302gene.^[5]^[6]

Function

[edit]

CD302 is aC-type lectin receptor involved incell adhesion andmigration, as well asendocytosis andphagocytosis.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000241399 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000060703 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994)."Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1".DNA Res.1 (1):27–35.doi:10.1093/dnares/1.1.27.PMID 7584026.
^Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994)."Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)".DNA Res.1 (1):47–56.doi:10.1093/dnares/1.1.47.PMID 7584028.
^Kato M, Khan S, d'Aniello E, McDonald KJ, Hart DN (November 2007)."The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration".J. Immunol.179 (9):6052–63.doi:10.4049/jimmunol.179.9.6052.PMID 17947679.

External links

[edit]

HumanCD302 genome location andCD302 gene details page in theUCSC Genome Browser.

Hillier LW, Graves TA, Fulton RS, et al. (2005)."Generation and annotation of the DNA sequences of human chromosomes 2 and 4".Nature.434 (7034):724–31.Bibcode:2005Natur.434..724H.doi:10.1038/nature03466.PMID 15815621.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Yang S, Noble CG, Yang D (2009). "Characterization of DLC1-SAM equilibrium unfolding at the amino acid residue level".Biochemistry.48 (19):4040–9.doi:10.1021/bi9000936.PMID 19317456.
Kato M, Khan S, Gonzalez N, et al. (2003)."Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1".J. Biol. Chem.278 (36):34035–41.doi:10.1074/jbc.M303112200.PMID 12824192.
Bonaldo MF, Lennon G, Soares MB (1996)."Normalization and subtraction: two approaches to facilitate gene discovery".Genome Res.6 (9):791–806.doi:10.1101/gr.6.9.791.PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.

v t e Proteins:clusters of differentiation (see alsolist of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 -CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 -CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Protein:lectins

Animal

C-type lectins	Asialoglycoprotein receptor KLRD1 Collectin Mannan-binding lectin Mannose receptor proteochondroitin sulfate Aggrecan Versican Brevican Neurocan
SIGLEC	Sialoadhesin CD22 CD33 Myelin-associated glycoprotein SIGLEC5 SIGLEC6 SIGLEC7 SIGLEC8 SIGLEC9 SIGLEC10 SIGLEC12
Other	Calnexin Calreticulin Galectin N-Acetylglucosamine receptor Selectin

Plant

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