Signal transducer CD24 also known ascluster of differentiation 24 orheat stable antigen CD24 (HSA) is aprotein that in humans is encoded by theCD24gene.[5] CD24 is acell adhesion molecule.
CD24 is asialoglycoprotein expressed at the surface of mostB lymphocytes and differentiatingneuroblasts. It is also expressed onneutrophils[6] and neutrophil precursors from themyelocyte stage onwards. The encoded protein is anchored via aglycosyl phosphatidylinositol (GPI) link to the cell surface. The protein also contributes to a wide range of downstream signaling networks and is crucial for neural development.[7] Cross-linking of CD24 on the surface of neutrophils inducesapoptosis,[8] and this appears to be defective insepsis.[8] CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined.[citation needed]
Researchers have identified CD24 as a novel cell surface marker that flags anastasis in melanoma cells, a process where cells that have initiated apoptosis can recover and survive.[9] This discovery highlights CD24’s role in marking apoptotic subpopulations that exhibit metabolic activity and proliferative capacities, contributing to melanoma’s resilience and potential metastasis.
Piotrowski P, Lianeri M, Wudarski M, Łacki JK, Jagodziński PP (June 2010). "CD24 Ala57Val gene polymorphism and the risk of systemic lupus erythematosus".Tissue Antigens.75 (6):696–700.doi:10.1111/j.1399-0039.2010.01447.x.PMID20230526.
Nagy B, Szendroi A, Romics I (June 2009). "Overexpression of CD24, c-myc and phospholipase 2A in prostate cancer tissue samples obtained by needle biopsy".Pathology & Oncology Research.15 (2):279–83.doi:10.1007/s12253-008-9077-1.PMID18752058.S2CID22572165.
Kim KH, Choi JS, Kim JM, Choi YL, Shin YK, Lee HC, et al. (March 2009). "Enhanced CD24 expression in endometrial carcinoma and its expression pattern in normal and hyperplastic endometrium".Histology and Histopathology.24 (3):309–16.doi:10.14670/HH-24.309.PMID19130400.
Bauerschmitz GJ, Ranki T, Kangasniemi L, Ribacka C, Eriksson M, Porten M, et al. (July 2008). "Tissue-specific promoters active in CD44+CD24-/low breast cancer cells".Cancer Research.68 (14):5533–9.doi:10.1158/0008-5472.CAN-07-5288.PMID18632604.
Sano A, Kato H, Sakurai S, Sakai M, Tanaka N, Inose T, et al. (February 2009). "CD24 expression is a novel prognostic factor in esophageal squamous cell carcinoma".Annals of Surgical Oncology.16 (2):506–14.doi:10.1245/s10434-008-0252-0.PMID19050962.S2CID30259987.
Gekara NO, Weiss S (November 2004). "Lipid rafts clustering and signalling by listeriolysin O".Biochemical Society Transactions.32 (Pt 5):712–4.doi:10.1042/BST0320712.PMID15493995.
Athanassiadou P, Grapsa D, Gonidi M, Athanassiadou AM, Tsipis A, Patsouris E (2009). "CD24 expression has a prognostic impact in breast carcinoma".Pathology, Research and Practice.205 (8):524–33.doi:10.1016/j.prp.2009.01.008.PMID19243896.
Ronaghi M, Vallian S, Etemadifar M (December 2009). "CD24 gene polymorphism is associated with the disease progression and susceptibility to multiple sclerosis in the Iranian population".Psychiatry Research.170 (2–3):271–2.doi:10.1016/j.psychres.2009.01.002.PMID19896210.S2CID35984512.
