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CD1A

From Wikipedia, the free encyclopedia
Protein-coding gene in humans

CD1A
Available structures
PDBHuman UniProt search:PDBeRCSB
List of PDB id codes

1ONQ,1XZ0,4X6C,4X6D,4X6E,4X6F

Identifiers
AliasesCD1A, CD1, FCB6, HTA1, R4, T6, CD1a molecule
External IDsOMIM:188370;HomoloGene:113556;GeneCards:CD1A;OMA:CD1A - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CD1A
Genomic location for CD1A
Band1q23.1Start158,254,424bp[1]
End158,258,269bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • thymus

  • skin of thigh

  • skin of hip

  • testicle

  • skin of arm

  • gums

  • gingival epithelium

  • skin of abdomen

  • monocyte

  • vulva
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

909

n/a

Ensembl

ENSG00000158477

n/a

UniProt

P06126

n/a

RefSeq (mRNA)

NM_001763
NM_001320652

n/a

RefSeq (protein)

NP_001307581
NP_001754

n/a

Location (UCSC)Chr 1: 158.25 – 158.26 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

CD1a (Cluster ofDifferentiation1a) is a humanprotein encoded by theCD1Agene.[3]

This gene encodes a member of theCD1 family of transmembrane glycoproteins, which are structurally related to themajor histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytotic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.[3] Transcript levels of theCD1A gene are upregulated in the lung parenchyma of smokers.[4]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000158477Ensembl, May 2017
  2. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ab"Entrez Gene: CD1A CD1a molecule".
  4. ^Pintarelli G, Noci S, Maspero D, Pettinicchio A, Dugo M, De Cecco L, Incarbone M, Tosi D, Santambrogio L, Dragani TA, Colombo F (September 2019)."Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients".Scientific Reports.9 (1): 13039.Bibcode:2019NatSR...913039P.doi:10.1038/s41598-019-49648-2.PMC 6736939.PMID 31506599.

External links

[edit]

Further reading

[edit]
PDB gallery
  • 1onq: Crystal Structure of CD1a in Complex with a Sulfatide
    1onq: Crystal Structure of CD1a in Complex with a Sulfatide
  • 1xz0: Crystal structure of CD1a in complex with a synthetic mycobactin lipopeptide
    1xz0: Crystal structure of CD1a in complex with a synthetic mycobactin lipopeptide

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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