CD1a (Cluster ofDifferentiation1a) is a humanprotein encoded by theCD1Agene.[3]
This gene encodes a member of theCD1 family of transmembrane glycoproteins, which are structurally related to themajor histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytotic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.[3] Transcript levels of theCD1A gene are upregulated in the lung parenchyma of smokers.[4]
Melián A, Beckman EM, Porcelli SA, Brenner MB (1996). "Antigen presentation by CD1 and MHC-encoded class I-like molecules".Curr. Opin. Immunol.8 (1):82–8.doi:10.1016/S0952-7915(96)80109-9.PMID8729450.
Coventry B, Heinzel S (2004). "CD1a in human cancers: a new role for an old molecule".Trends Immunol.25 (5):242–8.doi:10.1016/j.it.2004.03.002.PMID15099564.
Oakey RJ, Watson ML, Seldin MF (1993). "Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA".Hum. Mol. Genet.1 (8):613–20.doi:10.1093/hmg/1.8.613.PMID1301170.
