The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.[5] Abnormalities in CD151 have been implicated in a form of epidermolysis bullosa.[6][7]
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Fitter S, Seldin MF, Ashman LK (May 1998). "Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms".Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.1398 (1):75–85.doi:10.1016/S0167-4781(98)00034-7.PMID9602068.
Sincock PM, Fitter S, Parton RG, Berndt MC, Gamble JR, Ashman LK (March 1999). "PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function".Journal of Cell Science. 112 ( Pt 6) (6):833–844.doi:10.1242/jcs.112.6.833.hdl:2440/8940.PMID10036233.
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Whittock NV, McLean WH (February 2001). "Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene".Biochemical and Biophysical Research Communications.281 (2):425–430.Bibcode:2001BBRC..281..425W.doi:10.1006/bbrc.2001.4384.PMID11181065.
Kohno M, Hasegawa H, Miyake M, Yamamoto T, Fujita S (January 2002). "CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase".International Journal of Cancer.97 (3):336–343.doi:10.1002/ijc.1605.PMID11774285.S2CID46569418.
