CD11c, also known asIntegrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is agene that encodes for CD11c .[5][6]
CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of thealpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.[5]
Gaidano G, Bergui L, Schena M, et al. (1990). "Integrin distribution and cytoskeleton organization in normal and malignant monocytes".Leukemia.4 (10):682–7.PMID1976870.
Bernstein CN, Sargent M, Gallatin WM (1998). "Beta2 integrin/ICAM expression in Crohn's disease".Clinical Immunology and Immunopathology.86 (2):147–60.doi:10.1006/clin.1997.4462.PMID9473377.
Shelley CS, Da Silva N, Georgakis A, et al. (1998). "Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb".Genomics.49 (2):334–6.doi:10.1006/geno.1998.5232.PMID9598326.
