Chemokine (C-C motif) receptor 8, also known asCCR8, is aprotein which in humans is encoded by theCCR8gene.[5] CCR8 has also recently been designatedCDw198 (cluster of differentiation w198).
This gene encodes a member of the betachemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in thethymus. The ligand of the CCR8 isCCL1.[6] CCL8 also functions as a CCR8 agonist.[7]
Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis andthymic cellapoptosis. More specifically, this receptor may contribute to the proper positioning of activatedT cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.[5]
"Chemokine Receptors: CCR8".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2008-06-07. Retrieved2008-12-03.
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