Protein-coding gene in humans
C-C chemokine receptor type 4 is aprotein that in humans is encoded by theCCR4 gene .[ 5] [ 6] [ 7] CD194 (cluster of differentiation 194).
The protein encoded by this gene belongs to theG protein-coupled receptor family. It is a receptor for the followingCC chemokines :
Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types ofleukocytes . The chemokines also play fundamental roles in the development, homeostasis, and function of theimmune system , and they have effects on cells of thecentral nervous system as well as onendothelial cells involved inangiogenesis orangiostasis .[ 7]
CCR4 is a cell-surface protein and should not be confused with the unrelated carbon catabolite repression-negative on TATA-less (CCR4-Not ), a nuclear protein complex that regulates gene expression.
Clinical significance [ edit ] CCR4 is often expressed on leukemic cells incutaneous T-cell lymphoma (CTCL).[ 10]
Mogamulizumab is a humanisedmonoclonal antibody targeted at CCR4 and is aninvestigational drug for CTCL.[ 10]
^a b c GRCh38: Ensembl release 89: ENSG00000183813 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000047898 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Power CA, Meyer A, Nemeth K, Bacon KB, Hoogewerf AJ, Proudfoot AE, Wells TN (Sep 1995)."Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line" .J Biol Chem .270 (33):19495– 500.doi :10.1074/jbc.270.33.19495 PMID 7642634 . ^ Samson M, Soularue P, Vassart G, Parmentier M (Feb 1997). "The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3".Genomics .36 (3):522– 6.doi :10.1006/geno.1996.0498 .PMID 8884276 . ^a b "Entrez Gene: CCR4 chemokine (C-C motif) receptor 4" .^ Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (June 1997)."The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4" .J. Biol. Chem .272 (23):15036– 42.doi :10.1074/jbc.272.23.15036 PMID 9169480 . ^ Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW (January 1998)."Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4" .J. Biol. Chem .273 (3):1764– 8.doi :10.1074/jbc.273.3.1764 PMID 9430724 . ^a b FDA grants priority review to mogamulizumab for cutaneous T-cell lymphoma Nov 2017This article incorporates text from theUnited States National Library of Medicine , which is in thepublic domain .
1–50 51–100 101–150 151–200 201–250 251–300 301–350
