This gene is one of several CCcytokine genes clustered on thep-arm ofchromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory andinflammatory processes. The CC cytokines are proteins characterized by two adjacentcysteines. The protein encoded by this gene ischemotactic for skin-associatedmemory T lymphocytes. CCL27 is associated with homing of memoryT lymphocytes to theskin, and plays a role in T cell-mediatedinflammation of the skin.[6][7] CCL27 is expressed in numerous tissues, includinggonads,thymus,placenta andskin. It elicits itschemotactic effects by binding to the chemokine receptorCCR10.[8] The gene for CCL27 is located on humanchromosome 9.[9] Studies of a similarmurine protein indicate that these protein-receptor interactions have a pivotal role inT cell-mediatedskin inflammation. [provided by RefSeq, Sep 2014].
^Morales et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. U.S.A. 96:14470-14475, 1999.
^Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, et al. (February 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation".Nature Medicine.8 (2):157–65.doi:10.1038/nm0202-157.PMID11821900.S2CID35433583.
^Ishikawa-Mochizuki I, Kitaura M, Baba M, Nakayama T, Izawa D, Imai T, et al. (November 1999). "Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus".FEBS Letters.460 (3):544–8.Bibcode:1999FEBSL.460..544I.doi:10.1016/s0014-5793(99)01406-4.PMID10556532.S2CID39019419.
Kakinuma T, Saeki H, Tsunemi Y, Fujita H, Asano N, Mitsui H, et al. (March 2003). "Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris".The Journal of Allergy and Clinical Immunology.111 (3):592–7.doi:10.1067/mai.2003.114.PMID12642842.
Vestergaard C, Johansen C, Christensen U, Just H, Hohwy T, Deleuran M (September 2004). "TARC augments TNF-alpha-induced CTACK production in keratinocytes".Experimental Dermatology.13 (9):551–7.doi:10.1111/j.0906-6705.2004.00202.x.PMID15335355.S2CID84940084.
Vestergaard C, Johansen C, Otkjaer K, Deleuran M, Iversen L (January 2005). "Tumor necrosis factor-alpha-induced CTACK/CCL27 (cutaneous T-cell-attracting chemokine) production in keratinocytes is controlled by nuclear factor kappaB".Cytokine.29 (2):49–55.doi:10.1016/j.cyto.2004.09.008.PMID15598438.
Spiekstra SW, Toebak MJ, Sampat-Sardjoepersad S, van Beek PJ, Boorsma DM, Stoof TJ, et al. (February 2005). "Induction of cytokine (interleukin-1alpha and tumor necrosis factor-alpha) and chemokine (CCL20, CCL27, and CXCL8) alarm signals after allergen and irritant exposure".Experimental Dermatology.14 (2):109–16.doi:10.1111/j.0906-6705.2005.00226.x.PMID15679580.S2CID8770112.
Kagami S, Saeki H, Komine M, Kakinuma T, Nakamura K, Tsunemi Y, et al. (February 2006). "CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27".Experimental Dermatology.15 (2):95–100.doi:10.1111/j.1600-0625.2005.00390.x.PMID16433680.S2CID31590665.
