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CCL26

From Wikipedia, the free encyclopedia
Mammalian protein found in Homo sapiens
chemokine (C-C motif) ligand 26
Identifiers
SymbolCCL26
Alt. symbolsSCYA26, MIP-4alpha, eotaxin-3, IMAC, MIP-4a, TSC-1
NCBI gene10344
HGNC10625
OMIM604697
PDB1G2T
RefSeqNM_006072
UniProtQ9Y258
Other data
LocusChr. 7q11.2
Search for
StructuresSwiss-model
DomainsInterPro

Chemokine (C-C motif) ligand 26 (CCL26) is a smallcytokine belonging to the CCchemokine family that is also calledEotaxin-3, Macrophage inflammatory protein 4-alpha(MIP-4-alpha), Thymic stroma chemokine-1 (TSC-1), and IMAC. It is expressed by several tissues includingheart,lung andovary, and inendothelial cells that have been stimulated with thecytokineinterleukin 4.[1][2] CCL26 is chemotactic foreosinophils andbasophils and elicits its effects by binding to the cell surfacechemokine receptorCCR3.[3] This gene for chemokine is located on humanchromosome 7.[4]

References

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  1. ^Shinkai et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J. Immunol. 163:1602-1610, 1999.
  2. ^Guo et al. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. Genomics 58:313-317, 1999.
  3. ^Kitaura et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274:27975-27980, 1999.
  4. ^Hillier et al. The DNA sequence of human chromosome 7. Nature 424:157-164, 2003.

External links

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