Mammalian protein found in Homo sapiens
Chemokine (C-C motif) ligand 24 (CCL24) also known as myeloid progenitor inhibitory factor 2 (MPIF-2) or eosinophil chemotactic protein 2 (eotaxin-2) is aprotein that in humans is encoded by theCCL24 gene .[ 1] chromosome 7 .[ 2]
CCL24 is a smallcytokine belonging to the CCchemokine family. CCL24 interacts withchemokine receptor CCR3 to inducechemotaxis ineosinophils .[ 3] lymphocytes and slightly chemotactic forneutrophils .[ 1]
Clinical significance [ edit ] Elevated levels of eotaxin-2 has been seen in patients withaspirin-exacerbated respiratory disease (AERD), such as asthma. People with lower plasma levels of eotaxin-2 have not been showing tendency to develop aspirin inducible asthma.[ 4]
^a b Patel VP, Kreider BL, Li Y, Li H, Leung K, Salcedo T, Nardelli B, Pippalla V, Gentz S, Thotakura R, Parmelee D, Gentz R, Garotta G (April 1997)."Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors" .J. Exp. Med .185 (7):1163– 72.doi :10.1084/jem.185.7.1163 .PMC 2196270 PMID 9104803 . ^ Hillier LW, Fulton RS, Fulton LA, et al. (July 2003)."The DNA sequence of human chromosome 7" .Nature .424 (6945):157– 64.Bibcode :2003Natur.424..157H .doi :10.1038/nature01782 PMID 12853948 . ^ White JR, Imburgia C, Dul E, Appelbaum E, O'Donnell K, O'Shannessy DJ, Brawner M, Fornwald J, Adamou J, Elshourbagy NA, Kaiser K, Foley JJ, Schmidt DB, Johanson K, Macphee C, Moores K, McNulty D, Scott GF, Schleimer RP, Sarau HM (November 1997)."Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils" .J. Leukoc. Biol .62 (5):667– 75.doi :10.1002/jlb.62.5.667 PMID 9365122 .S2CID 12197497 . ^ Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS (October 2009)."Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease" .Allergy .65 (3):338– 346.doi :10.1111/j.1398-9995.2009.02158.x PMID 19796209 .S2CID 205404242 .
By family
By function/
