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CCL22

From Wikipedia, the free encyclopedia

Mammalian protein found in humans
CCL22
Identifiers
AliasesCCL22, A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1, C-C motif chemokine ligand 22
External IDsOMIM:602957;MGI:1306779;HomoloGene:7529;GeneCards:CCL22;OMA:CCL22 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for CCL22
Genomic location for CCL22
Band16q21Start57,358,783bp[1]
End57,366,189bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • appendix

  • mucosa of urinary bladder

  • lymph node

  • rectum

  • pharynx

  • palpebral conjunctiva

  • vulva

  • tonsil

  • epithelium of colon

  • skin of abdomen
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6367

20299

Ensembl

ENSG00000102962

n/a

UniProt

O00626

O88430

RefSeq (mRNA)

NM_002990

NM_009137

RefSeq (protein)

NP_002981

NP_033163

Location (UCSC)Chr 16: 57.36 – 57.37 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

C-C motif chemokine 22 is aprotein that in humans is encoded by theCCL22gene.[4][5][6]

Theprotein encoded by this gene is secreted bydendritic cells andmacrophages, and elicits its effects on its target cells by interacting with cell surfacechemokine receptors such asCCR4.[7] The gene for CCL22 is located in humanchromosome 16 in a cluster with otherchemokines calledCX3CL1 andCCL17.[8][9]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000102962 –Ensembl, May 2017
  2. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^Godiska R, Chantry D, Raport CJ, Sozzani S, Allavena P, Leviten D, Mantovani A, Gray PW (Jun 1997)."Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells".J Exp Med.185 (9):1595–604.doi:10.1084/jem.185.9.1595.PMC 2196293.PMID 9151897.
  5. ^Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (Oct 1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13".Cytogenet Cell Genet.81 (1):10–1.doi:10.1159/000015000.PMID 9691168.S2CID 46851784.
  6. ^"Entrez Gene: CCL22 chemokine (C-C motif) ligand 22".
  7. ^Vulcano M, Albanesi C, Stoppacciaro A, Bagnati R, D'Amico G, Struyf S, Transidico P, Bonecchi R, Del Prete A, Allavena P, Ruco LP, Chiabrando C, Girolomoni G, Mantovani A, Sozzani S (2001)."Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo".Eur. J. Immunol.31 (3):812–22.doi:10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L.hdl:11379/240109.PMID 11241286.
  8. ^Nomiyama H, Imai T, Kusuda J, Miura R, Callen DF, Yoshie O (1998). "Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13".Cytogenet. Cell Genet.81 (1):10–1.doi:10.1159/000015000.PMID 9691168.S2CID 46851784.
  9. ^Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q".Genomics.60 (3):295–308.doi:10.1006/geno.1999.5927.PMID 10493829.

Further reading

[edit]

External links

[edit]
By family
Chemokine
CCL
CXCL
CX3CL
XCL
TNF
Interleukin
Type I
(grouped by
receptor
subunit)
γ chain
β chain
IL6 like/gp130
IL12 family/IL12RB1
Other
Type II
IL10 family
Interferon
I
II
Ig superfamily
IL17 family
Other
By function/
cell
CC
CCR1
CCR2
CCR3
CCR4
CCR5
CCR6
CCR7
CCR8
CCR9
CCR10
CCR11
Ungrouped
CXC
CXCR1
(IL-8Rα)
CXCR2
(IL-8Rβ)
CXCR3
CXCR4
CXCR5
CXCR6
CXCR7
C (XC)
XCR1
CX3C
CX3CR1
Others
CCBP2
CMKLR1
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