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Chemokine (C-C motif) ligand 15 (CCL15) is a smallcytokine belonging to the CCchemokine family that is also known as leukotactin-1, MIP5 and HCC-2. CCL15 is expressed inliver,small intestine,colon, and in certainleukocytes andmacrophages of thelung.^[1] It ischemotactic forneutrophils,monocytes, andlymphocytes and elicits its effects by binding to cell surfacechemokine receptors likeCCR1 andCCR3.^[2]^[3] The human CCL15gene spans fourexons and is located in a head-to-tail orientation onchromosome 17 with the gene of another CC chemokine known asCCL14.^[4]

References

^Pardigol et al. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Proc. Natl. Acad. Sci. 95: 6308-6313, 1998.
^Youn et al. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immun. 159: 5201-5205, 1997.
^Coulin et al. Characterization of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines. Europ. J. Biochem. 248: 507-515, 1997.
^Naruse et al. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics 34: 236-240, 1996.

By family

CCL	CCL1 CCL2/MCP1 CCL3/MIP1α CCL4/MIP1β CCL5/RANTES CCL6 CCL7 CCL8 CCL9 CCL11 CCL12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18/PARC/DCCK1/AMAC1/MIP4 CCL19 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28
CXCL	CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17
CX3CL	CX3CL1
XCL	XCL1 XCL2

Type I
(grouped by
receptor
subunit)

γ chain	IL2/IL15 IL4/IL13 IL7 IL9 IL21
β chain	IL3 IL5 GMCSF
IL6 like/gp130	IL6 IL11 IL27 IL30 IL31 +non ILOSM LIF CNTF CTF1
IL12 family/IL12RB1	IL12 IL23 IL27 IL35
Other	IL14 IL16 IL32 IL34

I	IFNA1 IFNA2 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA21 IFNB1 IFNK IFNW1
II	IFNG

Other

By function/
cell

CCR1	Agonists:CCL4 (MIP-1β) CCL5 (RANTES) CCL6 CCL9 (CCL10) CCL14 CCL15 CCL16 CCL23
CCR2	Agonists:CCL2 CCL8 CCL12 CCL16 NAMs:Cenicriviroc (TAK-652, TBR-652)
CCR3	Agonists:CCL5 (RANTES) CCL7 CCL11 CCL13 CCL15 CCL18 CCL24 CCL26 CCL28
CCR4	Agonists:CCL3 (MIP-1α) CCL5 (RANTES) CCL17 CCL22 Antibodies:Mogamulizumab (against CCR4)
CCR5	Agonists:CCL3 (MIP-1α) CCL4 (MIP-1β) CCL5 (RANTES) CCL8 CCL11 CCL13 CCL14 CCL16 NAMs:Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies:PRO-140
CCR6	Agonists:CCL20
CCR7	Agonists:CCL19 CCL21
CCR8	Agonists:CCL1 CCL16
CCR9	Agonists:CCL25
CCR10	Agonists:CCL27 CCL28
CCR11	Agonists:CCL19 CCL21 CCL25
Ungrouped	Antibodies:Bertilimumab (against CCL11) Carlumab (against CCL2)

CXCR1 (IL-8Rα)	Agonists:CXCL6 Emoctakin Interleukin-8 (CXCL8, GCP-1) Antagonists:Navarixin NAMs:Ladarixin Reparixin (repertaxin)
CXCR2 (IL-8Rβ)	Agonists:CXCL1 (MGSA) CXCL2 CXCL3 CXCL5 CXCL6 CXCL7 Emoctakin Garnocestim Interleukin-8 (CXCL8, GCP-1) Antagonists:Danirixin Elubrixin Navarixin NAMs:Ladarixin Reparixin (repertaxin)
CXCR3	Agonists:CXCL4 (PF4) CXCL9 (MIG) CXCL10 (IP-10) CXCL11 (I-TAC) Iroplact Antibodies:Eldelumab (against CXCL10)
CXCR4	Agonists:MIF SDF-1 (CXCL12) Ubiquitin Antagonists:Mavorixafor Plerixafor (AMD3100) Antibodies:Ulocuplumab (against CXCR4)
CXCR5	Agonists:CXCL13
CXCR6	Agonists:CXCL16
CXCR7	Agonists:Conolidine CXCL11 (I-TAC) CCX771 LIH383 RTI-5152-12 SDF-1 (CXCL12) VUF15485 PAMs:Plerixafor (AMD3100)

XCR1	Agonists:Lymphotactin-α (XCL1) Lymphotactin-β (XCL2) Antibodies:Pateclizumab

CX3CR1	Agonists:Fractalkine (CX3CL1)

Others

CCBP2	Agonists:CC (β) chemokines
CMKLR1	Agonists:Chemerin Resolvin E1

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