Chemokine-binding protein 2 is aprotein that in humans is encoded by theCCBP2gene.[5][6][7]
This gene encodes abeta chemokine receptor, which is predicted to be a seven transmembrane protein similar toG protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues andhemopoietic cells. The expression of this receptor inlymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation ofleukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped tochromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.[7]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bonini JA, Martin SK, Dralyuk F, Roe MW, Philipson LH, Steiner DF (Dec 1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3".DNA Cell Biol.16 (10):1249–56.doi:10.1089/dna.1997.16.1249.PMID9364936.
Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome".Cytogenet. Cell Genet.87 (3–4):265–8.doi:10.1159/000015443.PMID10702689.S2CID1178132.
