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CAR-302,196

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
CAR-302,196
Identifiers
  • (1-methylpiperidin-4-yl) 2-cyclopentyl-2-hydroxypent-3-ynoate
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC16H25NO3
Molar mass279.380 g·mol−1
3D model (JSmol)
  • CN1CCC(CC1)OC(=O)C(O)(C#CC)C2CCCC2
  • InChI=1S/C16H25NO3/c1-3-10-16(19,13-6-4-5-7-13)15(18)20-14-8-11-17(2)12-9-14/h13-14,19H,4-9,11-12H2,1-2H3
  • Key:GKCPDYHGDHCIJL-UHFFFAOYSA-N
  (verify)

CAR-302,196 (also known asPCMG or just by its code number302196) is a moderately potent and relatively short lastinganticholinergicdeliriant drug, related to thechemical warfare agent3-Quinuclidinyl benzilate (QNB). It was developed under contract toEdgewood Arsenal during the 1960s as part of theUS military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB.

CAR-302,196 was found to be only around 1/4 the potency of QNB, but its onset of action was much faster at only a few minutes, and the duration far shorter at only 2–3 hours. A fast-acting and short-lasting anticholinergic drug was felt to be more desirable for some applications.[1][2]

See also

[edit]

References

[edit]
  1. ^National Research Council (US) Panel on Anticholinesterase Chemicals; National Research Council (US) Panel on Anticholinergic Chemicals (1982).Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents. Vol. 1. The National Academies Press. pp. 206–207.doi:10.17226/740.ISBN 978-0-309-07759-0.PMID 25032448.
  2. ^Ketchum JS (2006).Chemical Warfare Secrets Almost Forgotten. A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War. ChemBooks Inc.ISBN 978-1-4243-0080-8.
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