Calcium homeostasis modulator 1 (CALHM1) is a pore-forming subunit of avoltage-gated ion channel and a voltage-gated ATP channel that in humans is encoded by theCALHM1gene.[5][6]
CALHM1 was identified by a tissue-specific gene expression profiling approach[7] that screened for genes located on susceptibility loci for late-onsetAlzheimer's disease (AD) and that are preferentially expressed in the hippocampus,[5] a brain region affected early in AD. CALHM1 is a plasma membrane calcium-permeableion channel regulated by voltage and extracellular calcium levels.[8] The exact function of CALHM1 in the brain is not completely understood, but studies have shown that CALHM1 controls neuronal intracellular calcium homeostasis and signaling, as well as calcium-dependent neuronal excitability and memory in mouse models.[8][9][10] Recent data have also shown that CALHM1 might facilitate theproteolytic degradation of the cerebralamyloid beta peptide, a culprit in ADpathogenesis.[11]
Moreno-Ortega AJ, Ruiz-Nuño A, García AG, Cano-Abad MF (Jan 2010). "Mitochondria sense with different kinetics the calcium entering into HeLa cells through calcium channels CALHM1 and mutated P86L-CALHM1".Biochemical and Biophysical Research Communications.391 (1):722–6.doi:10.1016/j.bbrc.2009.11.127.PMID19944073.
Desharnais R, Godin G, Jobin J, Valois P, Ross A (Dec 1990). "Optimism and health-relevant cognitions after a myocardial infarction".Psychological Reports.67 (3 Pt 2):1131–1135.doi:10.2466/pr0.1990.67.3f.1131.PMID2084739.S2CID46335269.
Lv RJ, He JS, Fu YH, Shao XQ, Wu LW, Lu Q, Jin LR, Liu H (Apr 2011). "A polymorphism in CALHM1 is associated with temporal lobe epilepsy".Epilepsy & Behavior.20 (4):681–5.doi:10.1016/j.yebeh.2011.02.007.PMID21439911.S2CID45287698.
