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C-8813

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Chemical compound

Pharmaceutical compound

C-8813
Identifiers


IUPAC name trans-4-(p-Bromophenyl)-4-(dimethylamino)-1-(2-(thiophen-2-yl)ethyl)cyclohexanol
CAS Number	616898-54-5^N
PubChemCID	11058633
ChemSpider	48059007^N
UNII	D343S4VX5G
Chemical and physical data
Formula	C₂₀H₂₆BrNOS
Molar mass	408.40 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES BrC1=CC=C([C@@]2(CC[C@](CC2)(CCC3=CC=CS3)O)N(C)C)C=C1
InChI InChI=1S/C20H26BrNOS/c1-22(2)20(16-5-7-17(21)8-6-16)13-11-19(23,12-14-20)10-9-18-4-3-15-24-18/h3-8,15,23H,9-14H2,1-2H3/t19-,20-^N Key:XRDNIYBVNZLPJE-MXVIHJGJSA-N^N
^NY (what is this?) (verify)

C-8813 (thiobromadol) is a potentμ-opioid receptor agonist with a distinctive chemical structure which is not closely related to other established families of opioid drugs. Thetrans-isomer was found to be around 591 times more potent thanmorphine in animal studies.^[1] The same study assigned a potency of 504 times that of morphine to the related compoundBDPC.

C-8813 is claimed to be similarly potent at theδ-opioid receptor, which antagonizes the μ-induced depression of breathing, presumably making the drug safer.^[1]

C-8813 has never been approved for use in humans.^{[citation needed]}

References

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^^a ^bLiu ZH, Jin WQ, Dai QY, Chen XJ, Zhang HP, Chi ZQ (May 2003). "Opioid activity of C8813, a novel and potent opioid analgesic".Life Sciences.73 (2):233–41.doi:10.1016/S0024-3205(03)00263-7.PMID 12738037.