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Bufuralol

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Bufuralol
Names

Preferred IUPAC name 2-(tert-Butylamino)-1-(7-ethyl-1-benzofuran-2-yl)ethan-1-ol
Other names 2-(tert-Butylamino)-1-(7-ethylbenzofuran-2-yl)ethan-1-ol 2-(tert-Butylamino)-1-(7-ethyl-1-benzofuran-2-yl)ethanol
Identifiers
CAS Number	54340-62-4^Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL296035
ChemSpider	64777
ECHA InfoCard	100.053.720
PubChem CID	71733
UNII	891H89GFT4
CompTox Dashboard(EPA)	DTXSID30866414
InChI InChI=1S/C16H23NO2/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4/h6-9,13,17-18H,5,10H2,1-4H3
SMILES OC(c2oc1c(cccc1c2)CC)CNC(C)(C)C
Properties
Chemical formula	C₁₆H₂₃NO₂
Molar mass	261.365 g·mol⁻¹
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). Infobox references

Chemical compound

Bufuralol is a potentbeta-adrenoceptor antagonist withpartial agonist activity.^[1] It is metabolized byCYP2D6.^[2]

Mostbeta blockers are aryloxypropanolamine-based. In this rare exception, the benzofuran oxygen is part of a ring rather than derived from theepichlorohydrin precursor.

References

[edit]

^Pringle, TH; Francis, RJ; East, PB; Shanks, RG (1986)."Pharmacodynamic and pharmacokinetic studies on bufuralol in man".British Journal of Clinical Pharmacology.22 (5):527–34.doi:10.1111/j.1365-2125.1986.tb02931.x.PMC 1401192.PMID 2878678.
^Flockhart DA (2007)."Drug Interactions: Cytochrome P₄₅₀ Drug Interaction Table".Indiana University School of Medicine. Retrieved on July 2011

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