Bone morphogenetic protein 5 is aprotein that in humans is encoded by theBMP5gene.[5][6][7]
Theprotein encoded by this gene is member of theTGFβ superfamily.Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP5 may play a role in certaincancers. Like other BMP's BMP5 is inhibited bychordin andnoggin. It is expressed in thetrabecular meshwork andoptic nerve head and may have a role in the development and normal function. It is also expressed in thelung andliver.
This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralizedbone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.[7]
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
