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Bone morphogenetic protein 3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

Not to be confused withBMP-3.

BMP3

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2QCQ

Identifiers

Aliases

BMP3, BMP-3A, bone morphogenetic protein 3

External IDs

OMIM:112263;MGI:88179;HomoloGene:927;GeneCards:BMP3;OMA:BMP3 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q21.21	Start	81,030,708bp^[1]
Band	4q21.21	End	81,057,627bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5 E3\|5 48.24 cM	Start	99,002,274bp^[2]
Band	5 E3\|5 48.24 cM	End	99,032,255bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

muscle layer of sigmoid colon

testicle

rectum

transverse colon

mucosa of transverse colon

tibial nerve

olfactory zone of nasal mucosa

palpebral conjunctiva

gallbladder

epithelium of colon

Top expressed in

perichondrium

lower lip

upper lip

urinary bladder

nucleus pulposus

cervical ganglion

urethra

skeleton

facial skeleton

ureter

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	cytokine activity BMP receptor binding transforming growth factor beta receptor binding growth factor activity signaling receptor binding
Cellular component	extracellular region extracellular exosome extracellular space
Biological process	regulation of apoptotic process skeletal system development cell differentiation regulation of MAPK cascade SMAD protein signal transduction cell development ossification cell-cell signaling positive regulation of pathway-restricted SMAD protein phosphorylation BMP signaling pathway multicellular organism development cartilage development osteoblast differentiation regulation of signaling receptor activity
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


651


110075

Ensembl


ENSG00000152785


ENSMUSG00000029335

UniProt


P12645


Q8BHE5

RefSeq (mRNA)


NM_001201


NM_173404 NM_001310677

RefSeq (protein)


NP_001192


NP_001297606 NP_775580

Location (UCSC)

Chr 4: 81.03 – 81.06 Mb

Chr 5: 99 – 99.03 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Bone morphogenetic protein 3, also known asosteogenin, is aprotein in humans that is encoded by theBMP3gene.^[5]

The protein encoded by this gene is a member of thetransforming growth factor beta superfamily. It, unlike otherbone morphogenetic proteins (BMP's) inhibits the ability of other BMP's to induce bone and cartilage development. It is adisulfide-linkedhomodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors.It is highly expressed in fractured tissues.

Cancer

[edit]

BMP3 ishypermethylated in many cases ofcolorectal cancer (CRC) and hence along with other hypermethylated genes, may be used as abiomarker to detect early stage CRC.^[6]^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000152785 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000029335 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)".
^Rasmussen SL, Krarup HB, Sunesen KG, Pedersen IS, Madsen PH, Thorlacius-Ussing O (June 2016). "Hypermethylated DNA as a biomarker for colorectal cancer: a systematic review".Colorectal Disease.18 (6):549–61.doi:10.1111/codi.13336.PMID 26998585.S2CID 25724654.
^Kormi SM, Ardehkhani S, Kerachian MA (November 2017). "New insights into colorectal cancer screening and early detection tests".Colorectal Cancer.6 (2):63–68.doi:10.2217/crc-2017-0007.

External links

[edit]

HumanBMP3 genome location andBMP3 gene details page in theUCSC Genome Browser.

Dickinson ME, Kobrin MS, Silan CM, Kingsley DM, Justice MJ, Miller DA, Ceci JD, Lock LF, Lee A, Buchberg AM (March 1990). "Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci".Genomics.6 (3):505–20.doi:10.1016/0888-7543(90)90480-I.PMID 1970330.
Tabas JA, Zasloff M, Wasmuth JJ, Emanuel BS, Altherr MR, McPherson JD, Wozney JM, Kaplan FS (February 1991)."Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3".Genomics.9 (2):283–9.doi:10.1016/0888-7543(91)90254-C.PMID 2004778.
Paralkar VM, Nandedkar AK, Pointer RH, Kleinman HK, Reddi AH (October 1990)."Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen".The Journal of Biological Chemistry.265 (28):17281–4.doi:10.1016/S0021-9258(17)44900-3.PMID 2211625.
Rosen V, Wozney JM, Wang EA, Cordes P, Celeste A, McQuaid D, Kurtzberg L (1990). "Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone".Connective Tissue Research.20 (1–4):313–9.doi:10.3109/03008208909023902.PMID 2612162.
Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA (December 1988). "Novel regulators of bone formation: molecular clones and activities".Science.242 (4885):1528–34.Bibcode:1988Sci...242.1528W.doi:10.1126/science.3201241.PMID 3201241.
Faucheux C, Ulysse F, Bareille R, Reddi AH, Amédée J (December 1997)."Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation".Biochemical and Biophysical Research Communications.241 (3):787–93.doi:10.1006/bbrc.1997.7792.PMID 9434787.
Daluiski A, Engstrand T, Bahamonde ME, Gamer LW, Agius E, Stevenson SL, Cox K, Rosen V, Lyons KM (January 2001). "Bone morphogenetic protein-3 is a negative regulator of bone density".Nature Genetics.27 (1):84–8.doi:10.1038/83810.PMID 11138004.S2CID 205097212.
Jin Y, Lu HB, Liong E, Lau TY, Tipoe GL (October 2001). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors".Histology and Histopathology.16 (4):1013–9.PMID 11642720.
Kloen P, Di Paola M, Borens O, Richmond J, Perino G, Helfet DL, Goumans MJ (September 2003). "BMP signaling components are expressed in human fracture callus".Bone.33 (3):362–71.doi:10.1016/S8756-3282(03)00191-1.PMID 13678778.
Kang Q, Sun MH, Cheng H, Peng Y, Montag AG, Deyrup AT, Jiang W, Luu HH, Luo J, Szatkowski JP, Vanichakarn P, Park JY, Li Y, Haydon RC, He TC (September 2004). "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery".Gene Therapy.11 (17):1312–20.doi:10.1038/sj.gt.3302298.PMID 15269709.S2CID 24526533.
Chen AL, Fang C, Liu C, Leslie MP, Chang E, Di Cesare PE (November 2004)."Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage".Journal of Orthopaedic Research.22 (6):1188–92.doi:10.1016/j.orthres.2004.02.013.PMID 15475196.S2CID 11544281.

Cell signaling:TGFβ signaling pathway

TGF beta superfamily of ligands

Ligand ofACVR orTGFBR	TGF beta family TGF-β1 TGF-β2 TGF-β3 Activin and inhibin INHA INHBA INHBB INHBC Nodal
Ligand ofBMPR	Bone morphogenetic proteins BMP2 BMP3 BMP4 BMP5 BMP6 BMP7 BMP8a BMP8b BMP10 BMP15 Growth differentiation factors GDF1 GDF2 GDF3 GDF5 GDF6 GDF7 Myostatin/GDF8 GDF9 GDF10 GDF11 GDF15 Anti-müllerian hormone

TGF beta receptors
(Activin,BMP,family)

TGFBR1:	Activin type 1 receptors ACVR1 ACVR1B ACVR1C ACVRL1 BMPR1 BMPR1A BMPR1B
TGFBR2:	Activin type 2 receptors ACVR2A ACVR2B AMHR2 BMPR2
TGFBR3:	Betaglycan

Transducers/SMAD

Ligand inhibitors

Coreceptors

Other

SARA

TGFβ receptor superfamily modulators

Type I

ALK1 (ACVRL1)	Agonists:Activin (A,B,AB) Avotermin BMP (10) Cetermin GDF (2 (BMP9)) TGFβ (1,2,3) Antibodies:Ascrinvacumab Kinase inhibitors:K-02288 ML-347 (LDN-193719, VU0469381) Decoy receptors:Dalantercept Other inhibitors:Disitertide
ALK2 (ACVR1A)	Agonists:Activin (A,B,AB) AMH (MIS) Avotermin BMP (5,6,7,8A,8B) Eptotermin alfa TGFβ (1,2,3) Kinase inhibitors:DMH-1 DMH-2 Dorsomorphin (BML-275) K-02288 ML-347 (LDN-193719, VU0469381)
ALK3 (BMPR1A)	Agonists:AMH (MIS) BMP (2,4,5,6,7,8A,8B) Dibotermin alfa Eptotermin alfa Kinase inhibitors:DMH-2 Dorsomorphin (BML-275) K-02288
ALK4 (ACVR1B)	Agonists:Activin (A,B,AB) GDF (1,3,11 (BMP11)) Myostatin (GDF8) Nodal Antagonists:Inhibin (A,B) Lefty (1,2) Kinase inhibitors:A 83-01 SB-431542 SB-505124
ALK5 (TGFβR1)	Agonists:Avotermin GDF (10 (BMP3B),11 (BMP11)) TGFβ (1,2,3) Antibodies:Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors:A 83-01 D-4476 GW-788388 LY-364947 LY-2109761 Galunisertib (LY-2157299) R-268712 RepSox (E-616452, SJN-2511) SB-431542 SB-505124 SB-525334 SD-208
ALK6 (BMPR1B)	Agonists:BMP (2,4,5,6,7,8A,8B,15 (GDF9B)) Dibotermin alfa Eptotermin alfa GDF (5 (BMP14),6 (BMP13),7 (BMP12),9,15) Radotermin Kinase inhibitors:DMH-2 Dorsomorphin (BML-275) K-02288
ALK7 (ACVR1C)	Agonists:GDF (1,3,11 (BMP11)) Nodal Antagonists:Lefty (1,2) Kinase inhibitors:A 83-01 SB-431542 SB-505124

Type II

TGFβR2	Agonists:Avotermin GDF (10 (BMP3B)) TGFβ (1,2,3) Antibodies:Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors:DMH-2 LY-364947
BMPR2	Agonists:BMP (2,4,6,7,10) Dibotermin alfa Eptotermin alfa GDF (2 (BMP9),5 (BMP14),6 (BMP13),7 (BMP12)) Radotermin Antagonists:Inhibin (A,B)
ACVR2A (ACVR2)	Agonists:Activin (A,B,AB) BMP (2,4,5,6,7,8A,8B,15 (GDF9B)) Dibotermin alfa Eptotermin alfa GDF (1,3,5 (BMP14),6 (BMP13),7 (BMP12),9,11 (BMP11),15) Myostatin (GDF8) Nodal Radotermin Antagonists:Inhibin (A,B) Lefty (1,2) Decoy receptors:Sotatercept
ACVR2B	Agonists:Activin (A,B,AB) BMP (2,4,6,7) Dibotermin alfa Eptotermin alfa GDF (1,3,5 (BMP14),6 (BMP13),7 (BMP12)) Myostatin (GDF8) Nodal Osteogenin (BMP3, BMP3A) Radotermin Antagonists:Inhibin (A,B) Lefty (1,2) Decoy receptors:Ramatercept
AMHR2 (AMHR)	Agonists:AMH (MIS)