Mammalianbombesin-like peptides are widely distributed in thecentral nervous system as well as in thegastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors includegastrin-releasing peptide receptor,neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[7][8]
BB3 is aG protein-coupled receptor.[6] BB3 only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as anorphan receptor.[6][9][10]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Bombesin Receptors: BB3".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2007-10-25.
^abOhki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse".Brain Res.762 (1–2):165–72.doi:10.1016/S0006-8993(97)00380-6.PMID9262170.S2CID1012779.
Liu J, Lao ZJ, Zhang J, et al. (2002). "Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3)".Biochemistry.41 (28):8954–60.doi:10.1021/bi0202777.PMID12102638.
Hou X, Wei L, Harada A, Tatamoto K (2007). "Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells".Lung Cancer.54 (2):143–8.doi:10.1016/j.lungcan.2006.08.005.PMID16979789.
"Bombesin Receptors: BB3".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2007-10-25.
