Bisphenol F (BPF;4,4′-dihydroxydiphenylmethane) is anorganic compound with the chemical formula(HOC 6H 4) 2CH 2. It is structurally related tobisphenol A (BPA), a popular precursor for formingplastics, as both belong to the category of molecules known asbisphenols, which feature two phenol groups connected via a linking group. In BPF, the two aromatic rings are linked by amethylene connecting group. In response to concern about thehealth effects of BPA, BPF is increasingly used as a substitute for BPA.[1][2]
BPF is used in the manufacture ofplastics andepoxy resins.[3] It is used in the production of tank and pipe linings, industrial flooring, road and bridge deck toppings, structural adhesives, grouts, coatings and electrical varnishes.[4] BPF is also utilized in liners, lacquers, adhesives, plastics, and the coating of drinks and food cans.[3] BPF is found in dental materials, such as restorative materials, liners, adhesives, oral prosthetic devices and tissue substitutes.[3][1][5]
BPF is under preliminary research to determine its potential toxicity, which may include airway irritation if BPF dust is inhaled, and anallergic reaction if it is in contact with the skin.[9]
BPF is pervasive in the environment, appearing in river water, drinking water, and agricultural soil samples.[10] Biodegradation appears to be the most promising route for removal of BPA and related bisphenols. One degradation process converts BPA to the correspondingbenzophenone(HOC6H4)2CO, which is relatively labile.[11]
^Cabaton, Nicolas; Chagnon, Marie-Christine; Lhuguenot, Jean-Claude; Cravedi, Jean-Pierre; Zalko, Daniel (2006-12-27). "Disposition and metabolic profiling of bisphenol F in pregnant and nonpregnant rats".Journal of Agricultural and Food Chemistry.54 (26):10307–10314.Bibcode:2006JAFC...5410307C.doi:10.1021/jf062250q.ISSN0021-8561.PMID17177575.
^Cabaton, Nicolas; Zalko, Daniel; Rathahao, Estelle; Canlet, Cécile; Delous, Georges; Chagnon, Marie-Christine; Cravedi, Jean-Pierre; Perdu, Elisabeth (2008-10-01). "Biotransformation of bisphenol F by human and rat liver subcellular fractions".Toxicology in Vitro.22 (7):1697–1704.Bibcode:2008ToxVi..22.1697C.doi:10.1016/j.tiv.2008.07.004.ISSN0887-2333.PMID18672047.
^Dumont, Coralie; Perdu, Elisabeth; Sousa, Georges de; Debrauwer, Laurent; Rahmani, Roger; Cravedi, Jean-Pierre; Chagnon, Marie-Christine (2011-10-01). "Bis(hydroxyphenyl)methane—bisphenol F—metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes".Drug and Chemical Toxicology.34 (4):445–453.doi:10.3109/01480545.2011.585651.ISSN0148-0545.PMID21770713.S2CID25319579.
^"Bisphenol F: Toxicity". PubChem, US National Library of Medicine. 14 June 2025. Retrieved21 June 2025.
