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Bietaserpine

From Wikipedia, the free encyclopedia
Bietaserpine
Names
IUPAC name
Methyl 1-[2-(diethylamino)ethyl]-11,17α-dimethoxy-18β-[(3,4,5-trimethoxybenzoyl)oxy]-3β,20α-yohimban-16β-carboxylate
Systematic IUPAC name
Methyl (1S,2R,3R,4aS,13bR,14aS)-13-[2-(diethylamino)ethyl]-2,11-dimethoxy-3-[(3,4,5-trimethoxybenzoyl)oxy]-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2′,3′:3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard100.000.151Edit this at Wikidata
UNII
  • InChI=1S/C39H53N3O9/c1-9-40(10-2)15-16-42-29-20-25(45-3)11-12-26(29)27-13-14-41-22-24-19-33(37(49-7)34(39(44)50-8)28(24)21-30(41)35(27)42)51-38(43)23-17-31(46-4)36(48-6)32(18-23)47-5/h11-12,17-18,20,24,28,30,33-34,37H,9-10,13-16,19,21-22H2,1-8H3/t24-,28+,30-,33-,34+,37+/m1/s1 checkY
    Key: WFTSRDISOMSAQC-ZNFOTRSXSA-N checkY
  • COc1cc(cc(OC)c1OC)C(=O)O[C@@H]4C[C@@H]5CN6CCc3c(n(CCN(CC)CC)c2cc(OC)ccc23)[C@H]6C[C@@H]5[C@H](C(=O)OC)[C@H]4OC
Properties
C39H53N3O9
Molar mass707.865 g·mol−1
Pharmacology
C02AA07 (WHO)
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Chemical compound

Bietaserpine (INN), or1-[2-(diethylamino)ethyl]reserpine, is a derivative ofreserpine used as anantihypertensive agent. Like reserpine, bietaserpine is aVMAT inhibitor.[1]

References

[edit]
  1. ^Buckingham Jet al. (eds.) (1993).Dictionary of Natural Products, vol. 5, p. 4923, Boca Raton: Chapman & Hall/CRC.ISBN 978-0-412-46620-5. Retrieved on June 22, 2009 throughGoogle Book Search.
Sympatholytic (and closely related)antihypertensives (C02)
Sympatholytics
(antagonizeα-adrenergic
vasoconstriction)
Central
α2-Adrenergic receptor agonists
Adrenergic release inhibitors
Imidazoline receptor agonists
Ganglion-blocking/nicotinic antagonists
Peripheral
Indirect
Monoamine oxidase inhibitors
VMAT inhibitors
Tyrosine hydroxylase inhibitors
Direct
α1-Adrenergic receptor blockers
Non-selective α-adrenergic receptor blockers
Otherantagonists
Serotonin receptor antagonists
Endothelin receptor antagonists (forPHTooltip Pulmonary hypertension)
DATTooltip Dopamine transporter
(DRIsTooltip Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter
(NRIsTooltip Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter
(SRIsTooltip Serotonin reuptake inhibitors)
VMATsTooltip Vesicular monoamine transporters
Others


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