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| Other names | NNC 22-0010; NNC-22-0010; NNC220010; NNC2210; NNC-2210 |
| Drug class | DopamineD1 receptorantagonist |
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| Formula | C19H19BrClNO2 |
| Molar mass | 408.72 g·mol−1 |
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Berupipam (INNTooltip International Nonproprietary Name; developmental code nameNNC 22-0010) is aselectivedopamineD1 receptorantagonist of thebenzazepine group which was under development for the treatment ofpsychotic disorders but was never marketed.[1][2] It reachedphase 1clinical trials prior to the discontinuation of its development.[1]
Berupipam and closely related dopamine D1 receptor antagonists were reported to have been generallywell-tolerated in clinical trials, butside effects includedrestlessness,drowsiness, othercentral nervous system-relatedsymptoms, andorthostatic hypotension.[3]
Berupipam, inradiolabeled form, has been studied for use inpositron emission tomography (PET)imaging.[4][5][6] The drug was first described in thescientific literature by 1994.[3]
Berupipam (also known as NNC 22-0010), a dopamine antagonist with a high affinity and selectivity for D1 receptor has been studied for patients with psychotic disorders. Berupipam participated in phase I clinical trials; however, further development of this drug was discontinued
D1-antagonists are an area of active research. Although no results of widespread clinical testing have yet been published. phase I clinical trials presented by Dr M Sloth-Nielson from Novo Nordisk suggest that further investigation of the 3 novel drugs NNC 01-0687, NNC 01-0756 [odapipam] and NNC 22-0010 is warranted. The drugs were generally well tolerated, with restlessness, drowsiness and other CNS-related symptoms being the main effects observed. NNC 22-0010 50mg produced a moderate orthostatic hypotension in 2 volunteers.
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