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| Combination of | |
|---|---|
| Benzylpenicillin | antibiotic |
| Benzathine | stabilizer |
| Clinical data | |
| Trade names | Bicillin L-A,[1] Permapen, others |
| Other names | penicillin benzathine benzyl, benzathine penicillin, penicillin G benzathine, benzylpenicillin benzathine[2] |
| AHFS/Drugs.com | Professional Drug Facts |
| License data | |
| Pregnancy category |
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| Routes of administration | Intramuscular injection[3] |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| PubChemCID | |
| DrugBank |
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| ChemSpider |
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| UNII | |
| KEGG |
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| ChEBI | |
| ChEMBL | |
| E number | E708(antibiotics) |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.014.782 |
 N Y (what is this?) (verify) | |
Benzathine benzylpenicillin, also known asbenzathine penicillin G (BPG), is anantibiotic medication useful for the treatment of a number ofbacterial infections.[3] Specifically it is used to treatstrep throat,diphtheria,syphilis, andyaws.[3][5] It is also used to preventrheumatic fever.[5] It is given byinjection into a muscle.[3][5] It is known as "Peanut Butter Shot" in USmilitary slang due to its viscosity.[6]
Side effects includeallergic reactions includinganaphylaxis, and the site of injection is notoriously painful.[5] When used to treat syphilis aJarisch–Herxheimer reaction may occur.[5] It is not recommended in those with a history ofpenicillin allergy or those with syphilis involving thenervous system.[5][3] Use duringpregnancy is generally safe.[3] It is in thepenicillin andbeta lactam class of medications and works viabenzylpenicillin.[3][5] Thebenzathine component slowly releases the penicillin making the combination long acting.[7]
Benzathine benzylpenicillin was patented in 1950.[2][8] It is on theWorld Health Organization's List of Essential Medicines.[9]
It is used to treatstrep throat,diphtheria,syphilis, andyaws.[3][5]
A single large 1.2-million-unit dose of intramuscular BPG is given to US military recruits. The Army in particular has a policy to inject all recruits if not allergic, though supply issues and individual base choices have reduced the coverage. A retrospective analysis shows that it reduces the rate of all-cause acute respiratory disease by 32% among Army recruits.[10]
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The possible adverse effects are generally similar to other forms of penicillin. BPG is overall well-tolerated, but pain from the injection site is a common concern.[11]
It is marketed by Pfizer (formerly by Wyeth) under the trade nameBicillin L-A.[12]
