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Benactyzine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Benactyzine
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)[1]
  • In general: ℞ (Prescription only)
Identifiers
  • 2-(diethylamino)ethyl hydroxy(diphenyl)acetate
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.005.568Edit this at Wikidata
Chemical and physical data
FormulaC20H25NO3
Molar mass327.424 g·mol−1
3D model (JSmol)
  • O=C(OCCN(CC)CC)C(O)(c1ccccc1)c2ccccc2
  • InChI=1S/C20H25NO3/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,23H,3-4,15-16H2,1-2H3 checkY
  • Key:IVQOFBKHQCTVQV-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Benactyzine is ananticholinergicdrug that was used in the treatment ofclinical depression andanxiety disorders before it was pulled from the U.S. market by theFDA due to serious side effects.[2]

Its use for these indications was limited byside effects such asdry mouth andnausea, and at high doses it can cause more severe symptoms such asdeliriant andhallucinogenic effects.[2] "Large doses of benactyzine in normal subjects may produce a state resembling the action ofmescaline orLSD."[3]

Brand names have included:Suavitil,Phebex,Phobex,Cedad,Cevanol,Deprol,Lucidil,Morcain,Nutinal,Parasan. While there was some tentative evidence of effectiveness when combined withmeprobamate, with the medication no longer available it is not clinically important.[4]

History

[edit]

Benactyzine was brought to market in the US in 1957 byMerck under the tradename, Suavitil.[5]

See also

[edit]

References

[edit]
  1. ^Anvisa (2023-03-31)."RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União (published 2023-04-04).Archived from the original on 2023-08-03. Retrieved2023-08-16.
  2. ^abShorter E (December 2002). "Looking backwards: a possible new path for drug discovery in psychopharmacology".Nature Reviews. Drug Discovery.1 (12):1003–1006.doi:10.1038/nrd964.PMID 12461521.S2CID 23439533.
  3. ^Fisher S (1959).Child Research In Psychopharmacology (1st ed.). Springfield, Illinois: Charles C Thomas Pub. p. 13.
  4. ^DeBattista AF, Schatzberg JO, Cole C (2010).Manual of clinical psychopharmacology (7th ed.). Washington, DC: American Psychiatric Pub. p. 423.ISBN 978-1-58562-377-8.
  5. ^Smith MC (2013)."Market Behavior".Principles of Pharmaceutical Marketing (Third ed.). New York: Routledge.ISBN 978-1-317-94071-5.

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Retrieved from "https://en.wikipedia.org/w/index.php?title=Benactyzine&oldid=1268906347"
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