Inphysiology,base excess andbase deficit refer to an excess or deficit, respectively, in the amount ofbase present in the blood. The value is usually reported as a concentration in units of mEq/L (mmol/L), with positive numbers indicating an excess of base and negative a deficit. A typicalreference range for base excess is −2 to +2 mEq/L.^[1]

Comparison of the base excess with the reference range assists in determining whether anacid/base disturbance is caused by a respiratory, metabolic, or mixed metabolic/respiratory problem. Whilecarbon dioxide defines the respiratory component of acid–base balance, base excess defines the metabolic component. Accordingly, measurement of base excess is defined, under a standardized pressure of carbon dioxide, bytitrating back to a standardized bloodpH of 7.40.

The predominant base contributing to base excess isbicarbonate. Thus, a deviation of serum bicarbonate from the reference range is ordinarily mirrored by a deviation in base excess. However, base excess is a more comprehensive measurement, encompassing all metabolic contributions.

Base excess is defined as the amount of strong acid that must be added to each liter of fully oxygenated blood to return the pH to 7.40 at a temperature of 37°C and a pCO₂ of 40 mmHg (5.3 kPa).^[2] A base deficit (i.e., a negative base excess) can be correspondingly defined by the amount of strong base that must be added.

A further distinction can be made between actual and standard base excess:actual base excess is that present in the blood, whilestandard base excess is the value when thehemoglobin is at 5 g/dl. The latter gives a better view of the base excess of the entireextracellular fluid.^[3]

Base excess (or deficit) is one of several values typically reported with arterial blood gas analysis that is derived from other measured data.^[2]

The term and concept of base excess were first introduced byPoul Astrup andOle Siggaard-Andersen in 1958.

Base excess can be estimated from thebicarbonate concentration ([HCO₃⁻]) andpH by the equation:^[4]

${\displaystyle Baseexcess=0.93\times \left(\left[HC{O}_3^{-}\right]-24.4+14.8\times \left(pH-7.4\right)\right)}$

with units of mEq/L. The same can be alternatively expressed as

${\displaystyle Baseexcess=0.93\times [HC{O}_3^{-}]+13.77\times pH-124.58}$

Calculations are based on theHenderson-Hasselbalch equation:

${\displaystyle pH=pK+log\frac{[HC{O}_3^{-}]}{[C{O}_2]}}$

Ultimately the end result is:

${\displaystyle BE=0.02786\times PaC{O}_2\times {10}^{(pH-6.1)}+13.77\times pH-124.58}$

Base excess beyond the reference range indicates

• metabolic alkalosis, orrespiratory acidosis with renal compensation if too high (more than +2 mEq/L)
• metabolic acidosis, orrespiratory alkalosis with renal compensation if too low (less than −2 mEq/L)

Blood pH is determined by both a metabolic component, measured by base excess, and a respiratory component, measured by PaCO₂ (partial pressure ofcarbon dioxide). Often a disturbance in one triggers a partial compensation in the other. A secondary (compensatory) process can be readily identified because itopposes the observed deviation in blood pH.

For example, inadequate ventilation, a respiratory problem, causes a buildup of CO₂, hence respiratory acidosis; the kidneys then attempt to compensate for the low pH by raising blood bicarbonate. The kidneys only partially compensate, so the patient may still have a low blood pH, i.e. acidemia. In summary, the kidneys partially compensate for respiratory acidosis by raising blood bicarbonate.

A high base excess, thusmetabolic alkalosis, usually involves an excess ofbicarbonate. It can be caused by

• Compensation for primaryrespiratory acidosis
• Excessive loss of HCl in gastric acid by vomiting
• Renal overproduction of bicarbonate, in eithercontraction alkalosis orCushing's disease

A base deficit (a below-normal base excess), thusmetabolic acidosis, usually involves either excretion of bicarbonate or neutralization of bicarbonate by excess organic acids. Common causes include

• Compensation for primaryrespiratory alkalosis
• Diabetic ketoacidosis, in which high levels of acidicketone bodies are produced
• Lactic acidosis, due toanaerobic metabolism during heavy exercise orhypoxia
• Chronic kidney failure, preventing excretion of acid and resorption and production of bicarbonate
• Diarrhea, in which large amounts of bicarbonate are excreted
• Ingestion of poisons such asmethanol,ethylene glycol, or excessiveaspirin

The serumanion gap is useful for determining whether a base deficit is caused by addition of acid or loss of bicarbonate.

• Base deficit with elevated anion gap indicates addition of acid (e.g., ketoacidosis).
• Base deficit with normal anion gap indicates loss of bicarbonate (e.g., diarrhea). The anion gap is maintained because bicarbonate is exchanged forchloride during excretion.

• Acid–base homeostasis
• Metabolic acidosis /Metabolic alkalosis
• Arterial blood gas

• acid-base.com
• Anthology on Base Excess (O.Siggaard-Andersen)
• Emedicine: Lactic Acidosis

• Chemical pathology
• Diagnostic intensive care medicine

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• Short description is different from Wikidata
• Pages using infobox diagnostic with unknown parameters