Benacerraf was born inCaracas, Venezuela on October 29, 1920, to a Moroccan-VenezuelanSephardic Jewish father, Abraham Benacerraf, and Algerian Jewish mother, Henrietta Lasry.[6] His father was a textile merchant. His brother was philosopherPaul Benacerraf. He moved to Paris from Venezuela with his family in 1925. After going back to Venezuela, he emigrated to the U.S. in 1940. That same year, Benacerraf attendedLycée Français de New York, where he earned aBaccalauréat (an academic qualification French students achieve after high school and a diploma necessary to begin university studies).[10]
From his Nobel autobiography: "By that time, I had elected to study biology and medicine, instead of going into the family business, as my father would have wanted. I did not realize, however, that admission to Medical School was a formidable undertaking for someone with my ethnic and foreign background in the United States of 1942. In spite of an excellent academic record at Columbia, I was refused admission by the numerous medical schools I applied to and would have found it impossible to study medicine except for the kindness and support of George W. Bakeman, father of a close friend, who was then Assistant to the President of the Medical College of Virginia in Richmond. Learning of my difficulties, Mr. Bakeman arranged for me to be interviewed and considered for one of the two remaining places in the Freshman class."[9]
After his medical internship, US Army service (1945–48), and working at the military hospital ofNancy, France, he became a researcher atColumbia University College of Physicians and Surgeons (1948–50). He performed research in Paris (1950–56), relocated toNew York University (1956–68), moved to theNational Institutes of Health (1968–70), then joinedHarvard University medical school in Boston (1970–91) where he became the Fabyan Professor of comparative Pathology, concurrently serving theDana–Farber Cancer Institute (1980). He began studying allergies in 1948, and discovered the Ir (immune response) genes that governtransplant rejection in the 1960s. Including a variety of different editions, Benacerraf is an author of over 300 books and articles.[14]
At Columbia, Benacerraf got his start in immunology withElvin A. Kabat in 1948. He spent two years in Kabat's laboratory working on experimental hypersensitivity mechanisms.[11] He then moved to Paris because of family issues and accepted a position in Bernard Halpern's laboratory at theHôpital Broussais. Here he also formed a close relationship with Italian scientist Guido Biozzi. For six years he worked on the reticuloendothelial function in relation to immunity. The reticuloendothelial function is the white blood cells inside of a barrier tissue. While there they discovered techniques to study the clearance of particulate matter from the blood by the RES (reticuloendothelial system) and devised equations that govern this process in mammals. After six years, Baruj returned to the United States in 1956 because he could not establish his own independent laboratory in France. He was recruited to the faculty of New York University (NYU), established his own laboratory, and returned to his studies on hypersensitivity.[11]
In New York, Baruj worked with several other immunologists on different fields of hypersensitivity. After working in his New York lab, Baruj turned his attention towards the training of new scientists, and made the decision to devote himself to his laboratory practices, instead of the family business. At this time Baruj also made the discovery that would go on to win him the Nobel Prize. He noticed that if antigens (something that causes a reaction with the immune system) were injected into animals with a similar heredity, two groups emerged: responders and non-responders. He then conducted further study and found that the dominant autosomal genes, termed the immune response genes, determined the response to certain antigens. This complex process would lead to the understanding of how these genes determine immune responses.
His discovery still holds true, and more has been discovered over the last century. More than 30 genes have been discovered in a gene complex called the major histocompatibility complex. The histocompatibility complex is a complex part of DNA that controls the immune response. This research has also led to clarify autoimmune diseases such asmultiple sclerosis andrheumatoid arthritis.[9]
^"The Nobel Lectures in Immunology. The Nobel Prize for Physiology or Medicine, 1980 awarded to Baruj Benacerraf, Jean Daussett & George D. Snell".Scandinavian Journal of Immunology.35 (4):373–98. 1992.PMID1557610.
^Petrányi, G. (1981). "Nobel Prize winners in medicine for 1980. Immunogenetic significance of the main histocompatibility system (George Snell, Jean Dausset, Baruj Benacerraf)".Orvosi Hetilap.122 (14):835–837.PMID7019812.
