Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Bamipine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Bamipine
Clinical data
Trade namesSoventol
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral?, topical
ATC code
Identifiers
  • N-benzyl-1-methyl-N-phenyl-piperidin-4-amine
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.023.261Edit this at Wikidata
Chemical and physical data
FormulaC19H24N2
Molar mass280.415 g·mol−1
3D model (JSmol)
  • N(c1ccccc1)(Cc2ccccc2)C3CCN(C)CC3
  • InChI=1S/C19H24N2/c1-20-14-12-19(13-15-20)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17/h2-11,19H,12-16H2,1H3 checkY
  • Key:VZSXTYKGYWISGQ-UHFFFAOYSA-N checkY
  (verify)

Bamipine (trade nameSoventol)[1] is a pharmaceutical drug acting as anH1 antihistamine withanticholinergic properties.[2] It is used as anantipruritic ointment.[3] No oral use is known.[4]

Adverse effects

[edit]

Side effects are typical of an old (first-generation) antihistamine: tiredness in adults, agitation in children,mydriasis (dilation of the pupils). These effects are rare when bamipine is applied topically as an ointment. Allergic andhypersensitivity reactions are also rare. Acuteeczema can be worsened by bamipine ointment.[5]

Contraindications and interactions

[edit]

No clinically relevant contraindications or interactions with other drugs are known.[5]

Pharmacology

[edit]

Pharmacokinetics

[edit]

When applied topically, the maximal effect is reached after 20 to 60 minutes and lasts up to 48 hours. Bamipine is not absorbed through intact skin in relevant doses.[5]

References

[edit]
  1. ^Publishing, William Andrew (2013-10-22).Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. p. 523.ISBN 978-0-8155-1856-3.
  2. ^Vardanyan RS (2017)."Chapter 5: 4-Substituted and 1,4-Disubstituted Piperidines".Piperidine-based drug discovery. Amsterdam, Netherlands. p. 191.ISBN 978-0-12-813428-3.{{cite book}}: CS1 maint: location missing publisher (link)
  3. ^WO 0236163, Pairet M, Pieper MP, Meade CJ, Schmelzer C, "Pharmaceutical compositions containing tiotropium salts and antihistamines and their use", published 10 May 2002, assigned to Boehringer Ingelheim 
  4. ^International Drug Names: Bamipine.
  5. ^abcHaberfeld H, ed. (2015).Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Soventol-Gel.
Antihistamines fortopical use
Anesthetics for topical use
Others
Benzimidazoles(*)
Diarylmethanes
Ethylenediamines
Tricyclics
Others
Fortopical use
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(andprodrugs)
nAChRsTooltip Nicotinic acetylcholine receptors
Agonists
(andPAMsTooltip positive allosteric modulators)
Antagonists
(andNAMsTooltip negative allosteric modulators)
Precursors
(andprodrugs)
H1
Agonists
Antagonists
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists
Retrieved from "https://en.wikipedia.org/w/index.php?title=Bamipine&oldid=1100693532"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp