Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Balofloxacin

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Balofloxacin
Clinical data
ATC code
  • none
Identifiers
  • 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC20H24FN3O4
Molar mass389.427 g·mol−1
3D model (JSmol)
  • CNC1CCCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F
  • InChI=1S/C20H24FN3O4/c1-22-11-4-3-7-23(9-11)17-15(21)8-13-16(19(17)28-2)24(12-5-6-12)10-14(18(13)25)20(26)27/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27) checkY
  • Key:MGQLHRYJBWGORO-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Balofloxacin (INN) is afluoroquinoloneantibiotic. It is sold under the brand nameQ-Roxin inKorea, and under various names in India.[1] It is not approved by the FDA for use in the United States.

Pharmacodynamics

[edit]

Balofloxacin is afluoroquinolone that has a broad spectrum in vitro activity against a wide range ofGram-positive andGram-negative bacteria, with enhanced activity against Gram positive bacteria, including MRSA and Streptococcus pneumoniae.[2] It functions by inhibiting the action of DNA-gyrase, preventing bacterial cells from reproducing or repairing themselves, resulting in cellular death.[3]

Side Effects

[edit]

Vomiting, headache, dizziness, stomach pain, nausea, diarrhea and decreased liver function are the most common side effects. In rare cases, Balofloxacin can lead to or worsen tendinitis,[3] and muscular damage.[3]

See also

[edit]

References

[edit]
  1. ^Alksne L (February 2003). "Balofloxacin Choongwae".Current Opinion in Investigational Drugs.4 (2):224–9.PMID 12669387.
  2. ^"NCATS Inxight Drugs — BALOFLOXACIN".drugs.ncats.io. Retrieved2022-07-28.
  3. ^abc"BALOFLOXACINhome: Uses, Side Effects and Medicines | Apollo Pharmacy".www.apollopharmacy.in. Retrieved2022-07-28.
Antifolates
(inhibit bacterial
purine metabolism,
thereby inhibiting
DNA and RNA
synthesis)
DHFR inhibitor
Sulfonamides
(DHPS inhibitor)
Short-acting
Intermediate-acting
Long-acting
Other/ungrouped
Combinations
Other DHPS inhibitors
Quinolones
(inhibit bacterial
topoisomerase
and/orDNA gyrase,
thereby inhibiting
DNA replication)
1st generation
Fluoroquinolones
2nd generation
3rd generation
4th generation
Veterinary
Newer non-fluorinated
Related (DG)
Anaerobic DNA
inhibitors
Nitroimidazole derivatives
RNA synthesis
Rifamycins/
RNA polymerase
Lipiarmycins
Retrieved from "https://en.wikipedia.org/w/index.php?title=Balofloxacin&oldid=1287983907"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp