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| Trade names | Bactidol, others |
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| Routes of administration | Topical (mouthwash) |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.005.012 |
| Chemical and physical data | |
| Formula | C21H45N3 |
| Molar mass | 339.612 g·mol−1 |
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Hexetidine is an anti-bacterial and anti-fungal agent commonly used in both veterinary and human medicine. It is alocal anesthetic,astringent anddeodorant and hasantiplaque effects.[1]
Hexetidine is the medicinal ingredient inSterisol, which is labelled for the symptomatic treatment of:streptococcal pharyngitis ('strep throat'),tonsillitis,pharyngitis,laryngitis,gingivitis,ulcerative stomatitis,oral thrush andVincent's angina; postoperative hygiene following tonsillectomy, throat or oral surgery. Hexetidine is not the same asChlorhexidine, another chemical commonly used inmouthwash, or theantimicrobial drug Hexedene (C22H45N3).[2]
In the UK, hexetidine is the active ingredient in the medicatedmouthwash brandedOraldene. In Canada, hexetidine was the active ingredient in the medicatedmouthwash brandedSteri/sol which has been discontinued. It used to be produced byMcNeil Consumer Healthcare, a division ofJohnson & Johnson (originallyWarner–Lambert, then marketed byPfizer after its acquisition since 2007). Oraldene contains 0.1 g/100 ml of hexetidine. In some European countries, the gargle solution and mouth spray in bottles of 40 ml namedHexoral (by Mcneil) also contains 0.2% hexetidine as its active compound. In Greece it is calledHexalen mouth wash[3] (also available in spray). Hexetidine can also be found in the mouthwashBactidol (by Mcneil) which is sold in many Asian countries. In Germany, hexetidinevaginal suppositories brandedVagi-Hex are available to be used for vaginalantisepsis. They are also used in late pregnancy for reducing neonatal infectious mortality and morbidity due togroup B streptococcal infections;[4] nonetheless, hexetidine is to be used with care during pregnancy, and its vaginal use is counter-indicated in the first three months of pregnancy.[5]
