BOH-2C-B was not included or mentioned inAlexander Shulgin's bookPiHKAL (Phenethylamines I Have Known and Loved).[5] Subsequently,Daniel Trachsel listed BOHB's dose as 30mg or moreorally in his bookPhenethylamine: von der Struktur zur Funktion (Phenethylamines: From Structure to Function).[1]
BOH-2C-B is asubstituted phenethylamine.[2] It featuresmethoxy substituents at the 2- and 5-position of the ring, as well as a bromine at the 4-position.[2] A hydroxy group is present at the beta (β) position from the functional amine group connected to the alpha (α) carbon, giving rise to its name.[2]
BOH-2C-B was first described in a 2004 study byRichard Glennon and colleagues on β-oxygenated 5-HT2A serotonin receptor agonists, although it is not mentioned by name.[2] It was encountered as a noveldesigner drug in 2019.[3][4] However, it is said to have been on the market since 2015.[4]
BOH-2C-B is a controlled substance in the following countries:
Germany: BOH-2C-B is controlled under the New Psychoactive Substances Act (NpSG) as of November 26, 2016. Possession is illegal but not penalized.[7]
Netherlands:: BOH-2C-B is not specifically scheduled in the NL but may be considered a ring-derived analogue of 2-phenethylamine which would make it illegal under updates made to the Dutch Opium Act in February 2024.[8]
United Kingdom: BOH-2C-B is illegal to produce, supply or import under the Psychoactive Substance Act as of May 26, 2016.[9]
United States: BOH-2C-B is unscheduled in the U.S., but may be considered an analogue of 2C-B under the Federal Analogue Act, and thus a Schedule I drug.[10]
^abcdefgGlennon RA, Bondarev ML, Khorana N, Young R, May JA, Hellberg MR, et al. (November 2004). "Beta-oxygenated analogues of the 5-HT2A serotonin receptor agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane".Journal of Medicinal Chemistry.47 (24):6034–6041.doi:10.1021/jm040082s.PMID15537358.
^abhttps://isomerdesign.com/bitnest/external/EMCDDA/1-June-2020 "As of 16 June 2020, a total of 14 new psychoactive substances have been formally notified by the Member States so far this year. These comprise: • Arylalkylamines: 2 (BOH-PHP, BOH-2C-B)" [...] "14.BOH-2C-B (2-amino-1-(4-bromo-2,5-dimethoxyphenyl)ethanol) — arylalkylamine, customs seizure, Sweden, 9 April 2020 (also seized by Danish customs on 6 December 2019). Notified: 9 June 2020. EU-EWS-RCS-FN-2020-0014"
^Stalberga, D., Kronstrand, R., Schranz, B., van Zijl, N., Karlman, S., Aref, S., ... & Gréen, H. (2025). Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5HT2A receptor.https://doi.org/10.22541/au.176253891.19158813/v1
^"NpSG Neue-psychoaktive-Stoffe-Gesetz" [New Psychoactive Substances Act (NpSG)].Bundesrecht - tagaktuell konsolidiert - alle Fassungen seit 2006 [Federal law - consolidated daily - all versions since 2006] (in German). Retrieved2024-02-19.
^Ministerie van Binnenlandse Zaken en Koninkrijksrelaties (Ministry of the Interior and Kingdom Relations)."Opiumwet" [Opium Act].wetten.overheid.nl (in Dutch). Retrieved2024-02-19.
