BMP8B
Identifiers
Aliases	BMP8B, BMP8, OP2, bone morphogenetic protein 8b
External IDs	OMIM:602284;MGI:104515;HomoloGene:74865;GeneCards:BMP8B;OMA:BMP8B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 39,757,182bp[1] End 39,788,865bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 57.42 cM Start 123,206,438bp[2] End 123,237,045bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia spinal ganglia trigeminal ganglion jejunal mucosa tibial nerve retinal pigment epithelium sural nerve trabecular bone duodenum mucosa of colon Top expressed in decidua gastrula intestinal villus calvaria hair follicle molar jejunum embryo Ileal epithelium body of femur More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transforming growth factor beta receptor binding cytokine activity BMP receptor binding growth factor activity Cellular component extracellular region extracellular space Biological process regulation of apoptotic process multicellular organism development skeletal system development positive regulation of pathway-restricted SMAD protein phosphorylation cartilage development cell differentiation regulation of MAPK cascade SMAD protein signal transduction cell development BMP signaling pathway ossification regulation of signaling receptor activity Sources:Amigo /QuickGO
Orthologs Species Human Mouse Entrez 656 12163 Ensembl ENSG00000116985 ENSMUSG00000032726 UniProt P34820 P34821 RefSeq (mRNA) NM_001720 NM_001256019 NM_007558 RefSeq (protein) NP_001711 NP_001242948 NP_031584 Location (UCSC) Chr 1: 39.76 – 39.79 Mb Chr 4: 123.21 – 123.24 Mb PubMed search [3] [4]
Wikidata
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Bone morphogenetic protein 8B is aprotein that in humans is encoded by theBMP8Bgene.^[5][6][7]

The protein encoded by this gene is a member of theTGF-β superfamily. It has closesequence homology toBMP7 andBMP5 and is believed to play a role in bone and cartilage development. It has been shown to be expressed in thehippocampus ofmurineembryos.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralizedbone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.^[7]

• HumanBMP8B genome location andBMP8B gene details page in theUCSC Genome Browser.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

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