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BML-190

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
BML-190
Identifiers
  • 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-1-morpholin-4-ylethanone
CAS Number
PubChemCID
ChemSpider
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC23H23ClN2O4
Molar mass426.90 g·mol−1
3D model (JSmol)
  • C4COCCN4C(=O)Cc(c(c1cc2)cc2OC)c(C)n1C(=O)c3ccc(Cl)cc3
  • InChI=1S/C23H23ClN2O4/c1-15-19(14-22(27)25-9-11-30-12-10-25)20-13-18(29-2)7-8-21(20)26(15)23(28)16-3-5-17(24)6-4-16/h3-8,13H,9-12,14H2,1-2H3 ☒N
  • Key:BJSDNVVWJYDOLK-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

BML-190 (Indomethacin morpholinylamide) is a drug used in scientific research that acts as a selectiveCB2inverse agonist.[1] BML-190 is structurally derived from theNSAIDindomethacin but has a quite different biological activity.[2] The activity produced by this compound is disputed, with some sources referring to it as a CB2agonist rather than an inverse agonist;[3][4] this may reflect an error in classification, or alternatively it may produce different effects in different tissues, and more research is required to resolve this dispute.

References

[edit]
  1. ^New DC, Wong YH (February 2003)."BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates".FEBS Letters.536 (1–3):157–60.doi:10.1016/S0014-5793(03)00048-6.PMID 12586356.S2CID 38569901.
  2. ^Klegeris A, Bissonnette CJ, McGeer PL (June 2003)."Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor".British Journal of Pharmacology.139 (4):775–86.doi:10.1038/sj.bjp.0705304.PMC 1573900.PMID 12813001.
  3. ^Melck D, De Petrocellis L, Orlando P, Bisogno T, Laezza C, Bifulco M, Di Marzo V (January 2000)."Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation".Endocrinology.141 (1):118–26.doi:10.1210/endo.141.1.7239.PMID 10614630.
  4. ^Scutt A, Williamson EM (January 2007). "Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors".Calcified Tissue International.80 (1):50–9.doi:10.1007/s00223-006-0171-7.PMID 17205329.S2CID 23624771.
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