Bicaudal D cargo adaptor 2 is aprotein that in humans is encoded by theBICD2gene.[5][6]
This gene is one of two humanhomologs ofDrosophila bicaudal-D and a member of theBicoid family. It has been implicated indynein-mediated, minus end-directedmotility alongmicrotubules. It has also been reported to be aphosphorylation target of NIMA relatedkinase 8. Two alternative splice variants have been described.[6]
Mutations inBICD2 are associated with spinal muscular atrophy with lower extremity predominancetype 2A andtype 2B.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization".Nat. Biotechnol.24 (10):1285–92.doi:10.1038/nbt1240.PMID16964243.S2CID14294292.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry".Anal. Chem.76 (10):2763–72.doi:10.1021/ac035352d.PMID15144186.
Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, et al. (2003). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex".Nat. Cell Biol.4 (12):986–92.doi:10.1038/ncb891.PMID12447383.S2CID7953140.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells".Nat. Biotechnol.23 (1):94–101.doi:10.1038/nbt1046.PMID15592455.S2CID7200157.
