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CAS Number | |
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CompTox Dashboard(EPA) | |
ECHA InfoCard | 100.229.843![]() |
Chemical and physical data | |
Formula | C13H18Cl2N2 |
Molar mass | 273.20 g·mol−1 |
3D model (JSmol) | |
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BD1063 or1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine is a selectivesigma receptorantagonist, with a reportedbinding affinity ofKi = 9 ± 1 nM for thesigma-1 receptor and more than 49 times selectivity over thesigma-2 receptor.[1]
Consistent with other reportedsigma receptorantagonists, pretreating Swiss Webster mice with BD1063 significantly decreases the convulsivity and lethality of cocaine.[1]
In other animal studies, BD1063 blocks the effects ofMDMA,[2] and reduces alcohol intake in rodent models ofalcoholism.[3]