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BCL9L

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

BCL9L

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2XB1,4UP0,4UP5

Identifiers

Aliases

BCL9L, BCL9-2, DLNB11, B-cell CLL/lymphoma 9-like, B-cell CLL/lymphoma 9 like, B cell CLL/lymphoma 9 like, B9L, BCL9 like

External IDs

OMIM:609004;MGI:1933114;HomoloGene:65615;GeneCards:BCL9L;OMA:BCL9L - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q23.3	Start	118,893,875bp^[1]
Band	11q23.3	End	118,925,926bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 A5.2	Start	44,394,122bp^[2]
Band	9\|9 A5.2	End	44,423,193bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

granulocyte

right coronary artery

stromal cell of endometrium

right uterine tube

gastric mucosa

popliteal artery

tibial arteries

mucosa of ileum

right ovary

nipple

Top expressed in

basilar part of occipital bone

splanchnocranium

sphenoid bone

thyroid cartilage

basisphenoid

Meckel's cartilage

hyoid bone

Rostral migratory stream

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transcription coactivator activity beta-catenin binding
Cellular component	nucleolus nucleus nucleoplasm beta-catenin-TCF complex
Biological process	regulation of cell morphogenesis regulation of transcription, DNA-templated negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of epithelial to mesenchymal transition transcription, DNA-templated beta-catenin-TCF complex assembly canonical Wnt signaling pathway somatic stem cell population maintenance skeletal muscle cell differentiation positive regulation of transcription by RNA polymerase II
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


283149


80288

Ensembl


ENSG00000186174


ENSMUSG00000063382

UniProt


Q86UU0


Q67FY2

RefSeq (mRNA)


NM_182557 NM_001378213 NM_001378214


NM_030256 NM_001357490

RefSeq (protein)


NP_872363 NP_001365142 NP_001365143


NP_084532 NP_001344419

Location (UCSC)

Chr 11: 118.89 – 118.93 Mb

Chr 9: 44.39 – 44.42 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

B-cell CLL/lymphoma 9 like is aprotein that in humans is encoded by the BCL9Lgene.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000186174 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000063382 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: B-cell CLL/lymphoma 9 like". Retrieved2017-10-31.

Sampietro J, Dahlberg CL, Cho US, Hinds TR, Kimelman D, Xu W (2006)."Crystal structure of a beta-catenin/BCL9/Tcf4 complex".Mol. Cell.24 (2):293–300.doi:10.1016/j.molcel.2006.09.001.PMID 17052462.
Miller TC, Rutherford TJ, Johnson CM, Fiedler M, Bienz M (2010)."Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor".J. Mol. Biol.401 (5):969–84.doi:10.1016/j.jmb.2010.07.007.PMC 2927781.PMID 20637214.
Brembeck FH, Wiese M, Zatula N, Grigoryan T, Dai Y, Fritzmann J, Birchmeier W (2011)."BCL9-2 promotes early stages of intestinal tumor progression".Gastroenterology.141 (4):1359–70, 1370.e1–3.doi:10.1053/j.gastro.2011.06.039.PMID 21703997.
Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A, Aburatani H, Nakamura T, Akiyama T (2011)."Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway".Nat Commun.2: 548.Bibcode:2011NatCo...2..548M.doi:10.1038/ncomms1551.PMID 22109522.
Zatula N, Wiese M, Bunzendahl J, Birchmeier W, Perske C, Bleckmann A, Brembeck FH (2014)."The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis".Oncotarget.5 (16):6770–87.doi:10.18632/oncotarget.2252.PMC 4196162.PMID 25149534.
El-Hage P, Petitalot A, Monsoro-Burq AH, Maczkowiak F, Driouch K, Formstecher E, Camonis J, Sabbah M, Bièche I, Lidereau R, Lallemand F (2015)."The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells".Mol. Cancer Res.13 (5):902–12.doi:10.1158/1541-7786.MCR-14-0180.PMID 25678599.

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