The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) protein that belongs to theAP-1/ATF superfamily oftranscription factors. The leucine zipper of this protein mediates dimerization with members of theJun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.[7]
Mice without the BATF gene (BATFknockout mice) lacked a type of inflammatory immune cell (Th17) and were resistant to conditions that normally induces an autoimmune condition similar tomultiple sclerosis.[8]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (December 1995). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family".Oncogene.11 (11):2255–65.PMID8570175.
^Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S (May 1996). "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes".Biochem. Biophys. Res. Commun.222 (1):164–70.Bibcode:1996BBRC..222..164H.doi:10.1006/bbrc.1996.0700.PMID8630063.
^Wang X, Johansen LM, Tae HJ, Taparowsky EJ (1996). "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors".Biochem. Biophys. Res. Commun.229 (1):316–22.Bibcode:1996BBRC..229..316W.doi:10.1006/bbrc.1996.1799.PMID8954125.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J,Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437 (7062):1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID16189514.S2CID4427026.
Echlin DR, Tae HJ, Mitin N, Taparowsky EJ (2000). "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos".Oncogene.19 (14):1752–63.doi:10.1038/sj.onc.1203491.PMID10777209.S2CID21006485.
Meyer NP, Johansen LM, Tae HJ, Budde PP, Williams KL, Taparowsky EJ (1998). "Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1".Mamm. Genome.9 (10):849–52.doi:10.1007/s003359900881.PMID9745044.S2CID36362547.
Wang X, Johansen LM, Tae HJ, Taparowsky EJ (1997). "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors".Biochem. Biophys. Res. Commun.229 (1):316–22.Bibcode:1996BBRC..229..316W.doi:10.1006/bbrc.1996.1799.PMID8954125.
Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S (1996). "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes".Biochem. Biophys. Res. Commun.222 (1):164–70.Bibcode:1996BBRC..222..164H.doi:10.1006/bbrc.1996.0700.PMID8630063.
Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family".Oncogene.11 (11):2255–65.PMID8570175.
