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HLA-B associated transcript 3

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From Wikipedia, the free encyclopedia

(Redirected fromBAT3)

Protein-coding gene in the species Homo sapiens

BAG6

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1WX9,4DWF,4EEW,4WWR,4X86,2N9P

Identifiers

Aliases

BAG6, BAG-6, BAT3, D6S52E, G3, HLA-B associated transcript 3, BCL2 associated athanogene 6, BAG cochaperone 6

External IDs

OMIM:142590;MGI:1919439;HomoloGene:3409;GeneCards:BAG6;OMA:BAG6 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p21.33	Start	31,639,028bp^[1]
Band	6p21.33	End	31,652,705bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17 B1\|17 18.59 cM	Start	35,135,178bp^[2]
Band	17 B1\|17 18.59 cM	End	35,147,322bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right testis

left testis

right lobe of thyroid gland

right uterine tube

apex of heart

pituitary gland

ganglionic eminence

left lobe of thyroid gland

anterior pituitary

muscle of thigh

Top expressed in

seminiferous tubule

spermatid

spermatocyte

neural layer of retina

ventricular zone

muscle of thigh

superior frontal gyrus

dentate gyrus of hippocampal formation granule cell

yolk sac

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	ribosome binding misfolded protein binding Hsp70 protein binding polyubiquitin modification-dependent protein binding proteasome binding protein binding ubiquitin-specific protease binding ubiquitin protein ligase binding signaling receptor binding identical protein binding
Cellular component	cytoplasm cytosol membrane intracellular membrane-bounded organelle nucleoplasm BAT3 complex nucleus extracellular region extracellular exosome
Biological process	regulation of apoptotic process negative regulation of proteolysis intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator cell differentiation ubiquitin-dependent protein catabolic process kidney development embryo development lung development immune system process positive regulation of ERAD pathway protein stabilization negative regulation of apoptotic process internal peptidyl-lysine acetylation brain development intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of cell population proliferation synaptonemal complex assembly spermatogenesis negative regulation of proteasomal ubiquitin-dependent protein catabolic process protein localization to cytosolic proteasome complex involved in ERAD pathway maintenance of unfolded protein involved in ERAD pathway tail-anchored membrane protein insertion into ER membrane ER-associated misfolded protein catabolic process immune response-activating cell surface receptor signaling pathway apoptotic process natural killer cell activation proteasomal protein catabolic process ubiquitin-dependent ERAD pathway endoplasmic reticulum stress-induced pre-emptive quality control transport chromatin organization proteasome-mediated ubiquitin-dependent protein catabolic process regulation of embryonic development
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


7917


224727

Ensembl

ENSG00000204463 ENSG00000228760 ENSG00000234651 ENSG00000229524 ENSG00000096155
ENSG00000227761 ENSG00000233348


ENSMUSG00000024392

UniProt


P46379


Q9Z1R2

RefSeq (mRNA)

NM_001098534 NM_001199697 NM_001199698 NM_004639 NM_080702
NM_080703


NM_001252468 NM_001252469 NM_057171

RefSeq (protein)


NP_001092004 NP_001186626 NP_001186627 NP_542433 NP_542434

NP_001239397
NP_001239398
NP_476512
NP_001359189
NP_001359190

NP_001359191
NP_001359194
NP_001359195
NP_001359196
NP_001359197
NP_001359198
NP_001359199
NP_001359200
NP_001359201
NP_001359202
NP_001359203
NP_001359204
NP_001359205
NP_001359206
NP_001359207
NP_001359208
NP_001359209
NP_001359210
NP_001359211
NP_001359212
NP_001359213
NP_001359214
NP_001359215
NP_001359216
NP_001359217
NP_001359218
NP_001359219
NP_001359220
NP_001391257
NP_001391258
NP_001391259
NP_001391260
NP_001391256

Location (UCSC)

Chr 6: 31.64 – 31.65 Mb

Chr 17: 35.14 – 35.15 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Large proline-rich protein BAT3 is aprotein that in humans is encoded by theBAT3gene.^[5]^[6]

Acluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes forTNF alpha and TNF beta. These genes are all within the humanmajor histocompatibility complex class III region. The protein encoded by this gene is anuclear protein. It has been implicated in the control ofapoptosis and regulatingheat shock protein. There are three alternatively splicedtranscript variants described for this gene.^[6]

References

[edit]

^^a ^b ^cENSG00000228760, ENSG00000234651, ENSG00000229524, ENSG00000096155, ENSG00000227761, ENSG00000233348 GRCh38: Ensembl release 89: ENSG00000204463, ENSG00000228760, ENSG00000234651, ENSG00000229524, ENSG00000096155, ENSG00000227761, ENSG00000233348 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000024392 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Banerji J, Sands J, Strominger JL, Spies T (Apr 1990)."A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain".Proc Natl Acad Sci U S A.87 (6):2374–8.Bibcode:1990PNAS...87.2374B.doi:10.1073/pnas.87.6.2374.PMC 53689.PMID 2156268.
^^a ^b"Entrez Gene: BAT3 HLA-B associated transcript 3".

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References

Further reading