Movatterモバイル変換

Azapride

From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

Azapride
Clinical data

Other names	Azidoclebopride
ATC code	None
Identifiers
IUPAC name 4-Azido-5-chloro-2-methoxy-N-[1-(phenylmethyl)piperidin-4-yl]benzamide
CAS Number	92990-90-4^Y
PubChemCID	3036441
ChemSpider	2300456^Y
UNII	URS8YWT9Q7
CompTox Dashboard(EPA)	DTXSID00239217
Chemical and physical data
Formula	C₂₀H₂₂ClN₅O₂
Molar mass	399.88 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Clc1cc(c(OC)cc1/N=[N+]=[N-])C(=O)NC3CCN(Cc2ccccc2)CC3
InChI InChI=1S/C20H22ClN5O2/c1-28-19-12-18(24-25-22)17(21)11-16(19)20(27)23-15-7-9-26(10-8-15)13-14-5-3-2-4-6-14/h2-6,11-12,15H,7-10,13H2,1H3,(H,23,27)^Y Key:CKKHIIXHAWWTNP-UHFFFAOYSA-N^Y
(verify)

Azapride is theazide derivative of thedopamine antagonist clebopride synthesized in order to label dopamine receptors.^[1]^[2] It is an irreversibledopamine antagonist.^[2]

^Niznik HB, Guan JH, Neumeyer JL, Seeman P (February 1985). "A photoaffinity ligand for dopamine D2 receptors: azidoclebopride".Molecular Pharmacology.27 (2):193–9.doi:10.1016/S0026-895X(25)12275-X.PMID 3969068.
^^a ^bWouters W, Van Dun J, Laduron PM (December 1984)."Photoaffinity labelling of dopamine receptors. Synthesis and binding characteristics of azapride".European Journal of Biochemistry.145 (2):273–8.doi:10.1111/j.1432-1033.1984.tb08548.x.PMID 6548707.

Agonists	Benzazepines:6-Br-APB Fenoldopam SKF-38,393 SKF-77,434 SKF-81,297 SKF-82,958 SKF-83,959 Trepipam Zelandopam Ergolines:Cabergoline CY-208,243 Dihydroergocryptine LEK-8829 Lisuride Pergolide Terguride Dihydrexidine derivatives:A-77636 A-86929 Adrogolide (ABT-431, DAS-431) Dihydrexidine Dinapsoline Dinoxyline Doxanthrine Phenethylamines:BCO-001 Deoxyepinephrine (N-methyldopamine, epinine) Dopexamine Etilevodopa Ibopamine L-DOPA (levodopa) Melevodopa L-Phenylalanine L-Tyrosine XP21279 Others:A-68930 Apomorphine Isocorypalmine Nuciferine PF-6649751 PF 6669571 Propylnorapomorphine Rotigotine SKF-89,145 SKF-89,626 Stepholidine Tavapadon Tetrahydropalmatine
PAMs	Tetrahydroisoquinolines:DETQ DPTQ Mevidalen
Antagonists	Typical antipsychotics:Butaclamol Chlorpromazine Chlorprothixene Flupentixol (flupenthixol) (+melitracen) Fluphenazine Loxapine Perphenazine (+amitriptyline) Pifluthixol Thioridazine Thiothixene Trifluoperazine (+tranylcypromine) Zuclopenthixol Atypical antipsychotics:Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine (+fluoxetine) Paliperidone Quetiapine Risperidone Tefludazine Zicronapine Ziprasidone Zotepine Others:Berupipam Ecopipam EEDQ Metitepine (methiothepin) Odapipam Perlapine SCH-23390

Agonists

Antagonists

Thisdrug article relating to thenervous system is astub. You can help Wikipedia byexpanding it.

Hidden categories: