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Atagabalin

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Atagabalin
Clinical data
Other namesPD-0200390; PD-200390; PD0200390; PD200390
Routes of
administration
Oral[1]
ATC code
  • none
Identifiers
  • [(3S,4S)-1-(aminomethyl)-3,4-dimethylcyclopentyl]acetic acid
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC10H19NO2
Molar mass185.267 g·mol−1
3D model (JSmol)
  • C[C@H]1CC(C[C@@H]1C)(CC(=O)O)CN
  • InChI=1S/C10H19NO2/c1-7-3-10(6-11,4-8(7)2)5-9(12)13/h7-8H,3-6,11H2,1-2H3,(H,12,13)/t7-,8-/m0/s1 checkY
  • Key:IUVMAUQEZFTTFB-YUMQZZPRSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Atagabalin (INNTooltip International Nonproprietary Name,USANTooltip United States Adopted Name; developmental code namePD-0200390) is a drug developed byPfizer and related togabapentin, which similarly binds to the α2δcalcium channels (1 and2).[1][2] It was under development as a treatment forinsomnia, but was discontinued following unsatisfactory trial results.[1][3][4][5][6] The drug reachedphase 2clinical trials for this indication prior to the discontinuation of its development.[1]

See also

[edit]

References

[edit]
  1. ^abcd"Atagabalin".AdisInsight. 5 November 2023. Retrieved3 October 2025.
  2. ^Blakemore DC, Bryans JS, Carnell P, Carr CL, Chessum NE, Field MJ, Kinsella N, Osborne SA, Warren AN, Williams SC (January 2010). "Synthesis and in vivo evaluation of bicyclic gababutins".Bioorganic & Medicinal Chemistry Letters.20 (2):461–4.doi:10.1016/j.bmcl.2009.11.118.PMID 20005103.
  3. ^Atkin T, Comai S, Gobbi G (April 2018). "Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery".Pharmacol Rev.70 (2):197–245.doi:10.1124/pr.117.014381.PMID 29487083.
  4. ^Corrigan B, Feltner DE, Ouellet D, Werth JL, Moton AE, Gibson G (August 2009)."Effect of renal impairment on the pharmacokinetics of PD 0200390, a novel ligand for the voltage-gated calcium channel alpha-2-delta subunit".British Journal of Clinical Pharmacology.68 (2):174–80.doi:10.1111/j.1365-2125.2009.03444.x.PMC 2767279.PMID 19694735.
  5. ^Quintero JE, Pomerleau F, Huettl P, Johnson KW, Offord J, Gerhardt GA (May 2011)."Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: Basic characterization and drug pharmacology".Brain Research.1401:1–9.doi:10.1016/j.brainres.2011.05.025.PMC 3197737.PMID 21664606.
  6. ^Kjellsson MC, Ouellet D, Corrigan B, Karlsson MO (June 2011). "Modeling Sleep Data for a New Drug in Development using Markov Mixed-Effects Models".Pharmaceutical Research.28 (10):2610–27.doi:10.1007/s11095-011-0490-x.PMID 21681607.S2CID 22241527.
GABAA
Alcohols
Barbiturates
Benzodiazepines
Carbamates
Imidazoles
Monoureides
Neurosteroids
Nonbenzodiazepines
Phenols
Piperidinediones
Quinazolinones
Others
GABAB
H1
Antihistamines
Antidepressants
Antipsychotics
α2-Adrenergic
5-HT2A
Antidepressants
Antipsychotics
Others
Melatonin
Orexin
α2δVDCC
Others
Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
Activators
IRKsTooltip Inwardly rectifying potassium channel
Blockers
Activators
KCaTooltip Calcium-activated potassium channel
Blockers
Activators
K2PsTooltip Tandem pore domain potassium channel
Blockers
Activators
Sodium
VGSCsTooltip Voltage-gated sodium channels
Blockers
Activators
ENaCTooltip Epithelial sodium channel
Blockers
Activators
ASICsTooltip Acid-sensing ion channel
Blockers
Chloride
CaCCsTooltip Calcium-activated chloride channel
Blockers
Activators
CFTRTooltip Cystic fibrosis transmembrane conductance regulator
Blockers
Activators
Unsorted
Blockers
Others
TRPsTooltip Transient receptor potential channels
LGICsTooltip Ligand gated ion channels


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