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Asoprisnil

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Asoprisnil
Clinical data
ATC code
  • None
Identifiers
  • (8S,11R,13S,14S,17S)-11-[4-[(E)-hydroxyiminomethyl]phenyl]-17-methoxy-17-(methoxymethyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
CAS Number
PubChemCID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC28H35NO4
Molar mass449.591 g·mol−1
3D model (JSmol)
  • O=C5\C=C4/C(=C3/[C@@H](c1ccc(\C=N\O)cc1)C[C@]2([C@@H](CC[C@@]2(OC)COC)[C@@H]3CC4)C)CC5
  • InChI=1S/C28H35NO4/c1-27-15-24(19-6-4-18(5-7-19)16-29-31)26-22-11-9-21(30)14-20(22)8-10-23(26)25(27)12-13-28(27,33-3)17-32-2/h4-7,14,16,23-25,31H,8-13,15,17H2,1-3H3/b29-16+/t23-,24+,25-,27-,28+/m0/s1 checkY
  • Key:GJMNAFGEUJBOCE-MEQIQULJSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Asoprisnil (INN; developmental code nameJ-867) is asynthetic,steroidalselective progesterone receptor modulator that was under development bySchering andTAP Pharmaceutical Products for the treatment ofuterine fibroids.[1] In 2005,phase IIIclinical trials were discontinued due toendometrial changes in patients.[2]

See also

[edit]

References

[edit]
  1. ^DeManno D, Elger W, Garg R, et al. (2003). "Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy".Steroids.68 (10–13):1019–32.doi:10.1016/j.steroids.2003.09.008.PMID 14667995.S2CID 23074350.
  2. ^Schering Interim Report Q1-3 2005
GRTooltip Glucocorticoid receptor
Agonists
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others
PRTooltip Progesterone receptor
Agonists
Mixed
(SPRMsTooltip Selective progesterone receptor modulators)
Antagonists
mPRTooltip Membrane progesterone receptor
(PAQRTooltip Progestin and adipoQ receptor)
Agonists
Antagonists


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