TheAsboe-Hansen sign (also known as "indirect Nikolsky sign'"[1] or "Nikolsky II sign"[1]) refers to the extension of alarge blister to adjacent unblistered skin when pressure is put on the top of it.[2][3] It is seen along withNikolsky's sign, both used to assess the severity of some blistering diseases such aspemphigus vulgaris and severe bullous drug reactions.[4]
This sign is named for the Danish physicianGustav Asboe-Hansen (1917–1989), who first described it in 1960.[5]
^James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020)."2. Cutaneous signs and diagnosis".Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 13.ISBN978-0-323-54753-6.
^Freiman, Anatoli; Kalia, Sunil; O'Brien, Elizabeth A. (July 2006). "Dermatologic Signs".Journal of Cutaneous Medicine and Surgery.10 (4):175–182.doi:10.2310/7750.2006.00042.
