In biology,Archezoa is a term that has been introduced by several authors to refer to a group of organisms (a taxon). Authors includeJosef Anton Maximilian Perty,[1]Ernst Haeckel[2] and in the 20th century byThomas Cavalier-Smithin his classification system. Each author used the name to refer to different arrays of organisms. This reuse by later authors of the same taxon name for different groups of organisms is widely criticized in taxonomy because the inclusion of the name in a sentence (e.g. "Archezoa have no olfactory organs") does not make sense unless the particular usage is specified (e.g. "Archezoasensu Cavalier-Smith (1987) have no olfactory organs"). Nonetheless, all uses of 'Archezoa' are now obsolete.
Cavalier-Smith proposed the term 'Archezoa' for a paraphyletic (seeParaphyly) territory ofeukaryotes that primitively lacked mitochondria. Like Margulis and others before (seePelomyxa), Cavalier-Smith argued that the initial ancestor of eukaryotes emerged prior to the endosymbiotic acquisition (seeendosymbiosis) of mitochondria.[3] The same paraphyletic territory was referred to as 'Hypochondria' by others.[4] The argument for Archezoa sensu Cavalier-Smith was never universally accepted because of conflicting information, and was dropped when the contrary argument, that amitochondriates were descendants of eukaryotes with mitochondria, became dominant.
Eukaryotes that eventually acquired a bacterial endosymbiont that became the mitochondria were placed in a taxonomic group which Cavalier-Smith called the Metakaryota, whereas the Archezoa represented an earlierparaphyletic group to which Cavalier-Smith variously assigned the diplomonads,Entamoeba,Microsporidia, oxymonads, parabasalids (Parabasalids), pelobionts (seePelomyxa), retortamonads, trichomonads, andTrimastix[5] (seeCavalier-Smith's system of classification). With the rejection of 'Archeozoa', the meaning of the term 'Metakaryota' became the same as 'Eukaryota' (seeEukaryote), and Metakaryota became superfluous.
Eukaryotic protists lacking mitochondria were discovered to have experienced secondary mitochondrial loss, meaning that their ancestors once possessed mitochondria but that these mitochondria had, over time, been transformed, reduced, or lost. In some of these organisms, mitochondria had degraded into simpler double-membrane bound organelles known asmitosomes andhydrogenosomes. Some of both types of organelles are known to have fully lost their genome.[6][7]
Initial discoveries found that amitochondriate organisms appeared to express mitochondrial Hsp60 and Hsp70 proteins from the nuclear DNA of the organism. This indicated that the ancestors of these organisms once possessed mitochondria which expressed these proteins, but that these genes had migrated to their nuclear DNA over time as a result of endosymbiotic gene transfer.[8][9]
As a result, the argument that some extant eukaryotes lacking mitochondria had emerged from the eukaryotic lineage before mitochondria were acquired was falsified.[10]
An argument for the Archezoa group was that amitochondriate protists appeared to branch off early on from the eukaryotic lineage in phylogenetic analyses. This corroborated the supposition that Archezoa were more closely linked to primitive eukaryotes that evolved prior to the endosymbiotic process that generated the mitochondria.[3] However, this early divergence later turned out to be a class of systematic errors in phylogenetic analysis called "long branch attraction".[11][12]
