 | |
| Names | |
|---|---|
| IUPAC name 17-Oxo-5α-androstan-3α-yl β-D-glucopyranosiduronic acid | |
| Systematic IUPAC name (2S,3S,4S,5R,6R)-6-{[(3aS,3bR,5aS,7R,9aS,9bS,11aS)-9a,11a-Dimethyl-1-oxohexadecahydro-1H-cyclopenta[a]pheananthren-7-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid | |
| Other names ADT-G; 5α-Androstan-3α-ol-17-one 3-glucuronide | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChemSpider | |
| KEGG | |
| UNII | |
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| Properties | |
| C25H38O8 | |
| Molar mass | 466.571 g/mol |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Androsterone glucuronide (ADT-G) is a majorcirculating andurinarymetabolite oftestosterone anddihydrotestosterone (DHT).[1] It accounts for 93% of total androgen glucuronides in women.[1] ADT-G is formed fromandrosterone byUDP-glucuronosyltransferases, with the majorenzymes beingUGT2B15 andUGT2B17.[1] It is a marker ofacne in women whileandrostanediol glucuronide is a marker ofhirsutism (excess hair growth) in women.[2]
Quantification of ADT-G and 3α-diol-G levels inSerum (blood) is an effective means of assessing androgen content in blood and androgenic activity in women.[3] Androsterone glucuronide content can be estimated usingLiquid chromatography–mass spectrometry.[3][4] If an unusual level of ADT-G is observed in the blood (either an elevated or decreased amount), proper treatment plans can be developed in order to treat related symptoms.[3]
Elevated levels of androsterone glucuronide in the blood have been observed in adult females who present with inflammatory acne.[5] The introduction of therapeutic antiandrogen treatment and the use of an oralContraceptive by women who are affected with androsterone related acne can decrease the amount of inflammatory acne present.[5]
