German bioinformatician (born 1980)
Andreas Dräger (German: [anˈdʁeːas ˈdʁɛːɡɐ] ; born 20 September 1980) is a German bioinformatician who leads the research group forData Analytics andBioinformatics at theMartin Luther University of Halle-Wittenberg .
In high school, Dräger was fascinated bycomputer science and recent advancements ingenetics andbiotechnology in the late 1990s. When he learned about a new degree program that allowed combining those technologies, he was immediately inspired. So, Dräger studiedbioinformatics at theMartin Luther University of Halle-Wittenberg inHalle (Saale) from 2000 to 2006. He worked as an intern forgenome sequencing at theMax Planck Institute for Molecular Genetics ,Berlin . He prepared his thesis about heavy-metal-resistant bacteria at themicrobiology department of theUniversity of Illinois atChicago . Dräger earned hisdoctorate at the Center for Bioinformatics inTübingen (ZBIT), focusing on thedynamic simulation ofmetabolic networks in avirtual liver . During this time, he worked as a visiting research student forsoftware engineering atKeio University inYokohama in 2010. After returning from Japan, the Faculty of Science of theUniversity of Tübingen honored his thesis with the 2011 dissertation award.[ a]
In early 2011, Dräger received funding for an independent research project as a postdoctoral junior group leader. In 2013, he undertook another two-year postdoc program as a Marie-Curie research scholar inLa Jolla . He worked in the Systems Biology Research Group at theUCSD (the University of California,San Diego ). Upon returning to Tübingen in 2015, he founded an independent research group at the university. In 2018 he was appointed asjunior professor forComputational Systems Biology of Infections and Antimicrobial-Resistant Pathogens within Tübingen's newly established interfaculty Institute for Bioinformatics and Medical Informatics (IBMI). His research group belonged to Tübingen'sCluster of Excellence , "Controlling Microbes to Fight Infections" (CMFI). In February 2024, Dräger was appointed as a university professor and has since held the chair of data analytics and bioinformatics at theMartin Luther University of Halle-Wittenberg ,[ b] while his group remains part of the German National Center for Infection Research (DZIF) at theUniversity of Tübingen .
Andreas Dräger's research focuses onmathematical models of the metabolic mechanisms behind antibiotic resistance. The central aspect of his research group is thehuman microbiome living within the airways from thenasal cavities to thelung . Dräger aims to identify new ways to combat life-threatening bacterial[ 1] [ 2] and viral infections.[ 3] [ 4] Hospital-acquired infections of therespiratory tract have the highest priority of the effort because this often involves germs with multi-resistance against antibiotic treatment. Particularly harmful bacteria in this habitat includePseudomonas aeruginosa [ 5] [ 2] andStaphylococcus aureus .[ 1] Another research area involves risk groups, such ascystic fibrosis patients. Applyingmetabolic network modeling for this endeavor requires a comprehensive understanding of the underlying processes of mutual interactions betweenpathogens ,commensal bacteria , and theirhost .[ 6] [ 7]
This work also requires developing specialized software to create, analyze, and share computer models insystems biology in general. For this reason, the group is also actively involved in severalstandardization efforts in systems biology[ 8] that are part of the initiatives by theComputational Modeling in Biology Network of international researchers.Dräger sees improvedinteroperability and reuse of the developed computer models according to the principles ofFAIR data (findable, accessible, interoperable, and reusable) as a prerequisite for the reliable implementation ofcomputer simulation in biology.[ 9] To this end, Dräger and his group develop scientificopen-source software , such asJSBML orSBSCL .[ 10] In 2015, the scientific community elected him as an editor for developing the systems biologyfile format SBML and in 2018 as an editor for the graphical modeling languageSBGN .[ 11] In 2016, Dräger was one of the founders of the annual community meeting with a special interest in systems modeling (SysMod )[ 12] within theInternational Society of Computational Biology (ISCB) , where he served as thede facto chairman from 2018 until he stepped down in 2022.[ 13]
During theCOVID-19 pandemic , Dräger's work regarding computational modeling ofSARS-CoV-2 within human cells[ 14] [ 15] raised international interest[ c] [ d] [ e] [ f] [ g] [ h] [ i] because it predicted potentially exploitable targets for drug development. One of those is the human enzymeguanylate kinase . Dräger's ongoing work on this topic focuses on pandemic preparedness.[ 16]
Commitment and Volunteering [ edit ] For over three years, he offered a course inbioinformatics andsystems biology for high school students at the "Otto-Hahn" high school inNagold , including mentorship in theYouth Researches competition.[ j]
Appearances in news and public media (selection)[ edit ] ^a b Renz, Alina;Dräger, Andreas (2021)."Curating and Comparing 114 Strain-Specific Genome-Scale Metabolic Models ofStaphylococcus aureus " .npj Systems Biology and Applications .7 (1): 30.doi :10.1038/s41540-021-00188-4 .PMC 8241996 .PMID 34188046 .S2CID 233598683 . ^a b Payne, Dawson D.; Renz, Alina; Dunphy, Laura J.; Lewis, Taylor;Dräger, Andreas ; Papin, Jason A. (2021)."An updated genome-scale metabolic network reconstruction ofPseudomonas aeruginosa PA14 to characterize mucin-driven shifts in bacterial metabolism" (PDF) .npj Systems Biology and Applications .7 (1): 37.doi :10.1038/s41540-021-00198-2 .PMC 8501023 .PMID 34625561 .S2CID 232224404 . ^ Bernardes, Joana P.; Mishra, Neha; Tran, Florian; Bahmer, Thomas; Best, Lena; Blase, Johanna I.; Bordoni, Dora; Franzenburg, Jeanette; Geisen, Ulf; Josephs-Spaulding, Jonathan; Köhler, Philipp; Künstner, Axel; Rosati, Elisa; Aschenbrenner, Anna C.; Bacher, Petra; Baran, Nathan; Boysen, Teide; Brandt, Burkhard; Bruse, Niklas; Dörr, Jonathan;Dräger, Andreas ; Elke, Gunnar; Ellinghaus, David; Fischer, Julia; Forster, Michael; Franke, Andre; Franzenburg, Sören; Frey, Norbert; Friedrichs, Anette; Fuß, Janina; Glück, Andreas; Hamm, Jacob; Hinrichsen, Finn; Hoeppner, Marc P.; Imm, Simon; Juenker, Ralf; Kaiser, Sina; Kan, Ying H.; Knoll, Rainer; Lange, Christoph; Laue, Georg; Lier, Clemes; Lindner, Matthias; Marinos, Georgios; Markewitz, Robert; Nattermann, Jacob; Noth, Rainer; Pickkers, Peter; Rabe, Klaus F.; Renz, Alina; Roecken, Christoph; Rupp, Jan; Schaffarzyk, Annika; Scheffold, Alexander; Schulte-Schrepping, Jonas; Schunck, Domagoj; Skowasch, Dirk; Ulas, Thomas; Wandinger, Klaus-Peter; Wittig, Michael; Zimmermann, Johannes; Busch, Hauke; Hoyer, Bimba F.; Kaleta, Christoph; Heyckendorf, Jan; Kox, Matthijs; Rybniker, Jan; Schreiber, Stefan; Schultze, Joachim; Rosenstiel, Philip; Banovich, Nicholas E.; Desai, Tushar; Eickelberg, Oliver; Haniffa, Muzlifa; Horvath, Peter; Kropski, Jonathan A.; Lafyatis, Robert; Lundeberg, Joakim; Meyer, Kerstin; Nawijn, Martijn C.; Nikolic, Marko; Ordovas Montanes, Jose; Pe'er, Dana; Tata, Purushothama Rao; Rawlins, Emma; Regev, Aviv; Reyfman, Paul; Samakovlis, Christos; Schultze, Joachim; Shalek, Alex; Shepherd, Douglas; Spence, Jason; Teichmann, Sarah; Theis, Fabian; Tsankov, Alexander; van den Berge, Maarten; von Papen, Michael; Whitsett, Jeffrey; Zaragosi, Laure Emmanuelle; Angelov, Angel; Bals, Robert; Bartholomäus, Alexander; Becker, Anke; Bezdan, Daniela; Bonifacio, Ezio; Bork, Peer; Clavel, Thomas; Colme-Tatche, Maria; Diefenbach, Andreas; Dilthey, Alexander; Fischer, Nicole; Förstner, Konrad; Frick, Julia Stefanie; Gagneur, Julien; Goesmann, Alexander; Hain, Torsten; Hummel, Michael; Janssen, Stefan; Kalinowski, Jörn; Kallies, René; Kehr, Birte; Keller, Andreas; Kim-Hellmuth, Sarah; Klein, Christoph; Kohlbacher, Oliver; Korbel, Jan O.; Kurth, Ingo; Landthaler, Markus; Li, Yang; Ludwig, Kerstin; Makarewicz, Oliwia; Marz, Manja; McHardy, Alice; Mertes, Christian; Nöthen, Markus; Nürnberg, Peter; Ohler, Uwe; Ossowski, Stephan; Overmann, Jörg; Peter, Silke; Pfeffer, Klaus; Poetsch, Anna R.; Pühler, Alfred; Rajewsky, Niklaus; Ralser, Markus; Rieß, Olaf; Ripke, Stephan; Nunes da Rocha, Ulisses; Saliba, Antoine Emmanuel; Sander, Leif Erik; Sawitzki, Birgit; Schiffer, Philipp; Schulte, Eva Christina; Sczyrba, Alexander; Stegle, Oliver; Stoye, Jens; Vehreschild, Janne; Vogel, Jörg; Kleist, Max von; Walker, Andreas; Walter, Jörn; Wieczorek, Dagmar; Ziebuhr, John (2020)."Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells and plasmablasts as hallmarks of severe COVID-19 trajectories" .Immunity .53 (6): 1296–1314.e9.doi :10.1016/j.immuni.2020.11.017 .ISSN 1074-7613 .PMC 7689306 .PMID 33296687 .S2CID 227163641 . ^ Ostaszewski, Marek; et al. (2021)."COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms" .Molecular Systems Biology .17 (10) e10387.doi :10.15252/msb.202110387 .PMC 8524328 .PMID 34664389 .S2CID 239027089 . ^ Dahal, Sanjeev; Renz, Alina;Dräger, Andreas ; Yang, Laurence (2023)."Genome-scale model ofPseudomonas aeruginosa metabolism unveils virulence and drug potentiation" (PDF) .Communications Biology .6 (1): 165.doi :10.1038/s42003-023-04540-8 .PMC 9918512 .PMID 36765199 .S2CID 256702200 . ^ Renz, Alina; Widerspick, Lina;Dräger, Andreas (2021)."First Genome-Scale Metabolic Model ofDolosigranulum pigrum Confirms Multiple Auxotrophies" .Metabolites .11 (4): 232.doi :10.3390/metabo11040232 .PMC 8069353 .PMID 33918864 .S2CID 233395707 . ^ Brunk, Elizabeth; Sahoo, Swagatika; Zielinski, Daniel C.; Altunkaya, Ali;Dräger, Andreas ; Mih, Nathan; Gatto, Francesco; Nilsson, Avlant; Preciat Gonzalez, German Andres; Aurich, Maike Kathrin; Prlić, Andreas; Sastry, Anand; Danielsdóttir, Anna D.; Heinken, Almut; Noronha, Alberto; Rose, Peter W.; Burley, Stephen K.; Fleming, Ronan M. T.; Nielsen, Jens; Thiele, Ines; Palsson, Bernhard O. (2018)."Recon3D enables a three-dimensional view of gene variation in human metabolism" .Nature Biotechnology .36 (3):272– 281.doi :10.1038/nbt.4072 .PMC 5840010 .PMID 29457794 .S2CID 210902494 . ^ Dräger, Andreas ; Waltemath, Dagmar (2021). "Overview: Standards for Modeling in Systems Medicine".Systems Medicine . pp. 345– 353.doi :10.1016/B978-0-12-816077-0.00001-7 .ISBN 978-0-12-816078-7 .S2CID 224975951 .^ Dräger, Andreas (2014)."Improving collaboration by standardization efforts in systems biology" .Frontiers in Bioengineering and Biotechnology .2 (61): 61.doi :10.3389/fbioe.2014.00061 .PMC 4259112 .PMID 25538939 .S2CID 16722945 .^ Panchiwala, Hemil; Shah, Shalin; Planatscher, Hannes; Zakharchuk, Mykola; König, Matthias;Dräger, Andreas (2022)."The Systems Biology Simulation Core Library" .Bioinformatics .38 (3):864– 865.doi :10.1093/bioinformatics/btab669 .PMC 8756180 .PMID 34554191 .S2CID 230546045 . ^ Touré, Vasundra;Dräger, Andreas ;Luna, Augustin ; Dogrusoz, Ugur; Rougny, Adrien (2021). "The Systems Biology Graphical Notation: Current Status and Applications in Systems Medicine".Systems Medicine . pp. 372– 381.doi :10.1016/B978-0-12-801238-3.11515-6 .ISBN 978-0-12-816078-7 .S2CID 213385953 . ^ Dräger, Andreas ; Helikar, Tomáš; Barberis, Matteo; Birtwistle, Marc; Calzone, Laurence; Chaouiya, Claudine; Hasenauer, Jan; Karr, Jonathan R.; Niarakis, Anna; Rodríguez Martínez, María; Saez-Rodriguez, Julio; Thakar, Juilee (2021)."SysMod: the ISCB community for data-driven computational modelling and multi-scale analysis of biological systems" (PDF) .Bioinformatics .37 (21):3702– 3706.doi :10.1093/bioinformatics/btab229 .PMC 8570808 .PMID 34179955 .S2CID 234620344 .^ Niarakis, Anna; Thakar, Juilee; Barberis, Matteo; Rodríguez Martínez, María; Helikar, Tomáš; Birtwistle, Marc; Chaouiya, Claudine; Calzone, Laurence;Dräger, Andreas (2022)."Computational modelling in health and disease. Highlights of the 6th annual SysMod meeting" (PDF) .Bioinformatics .38 (21):4990– 4993.doi :10.1093/bioinformatics/btac609 . ^ Renz, Alina; Widerspick, Lina;Dräger, Andreas (2020)."FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2" (PDF) .Bioinformatics .36 (Suppl 2):i813 – i821 .doi :10.1093/bioinformatics/btaa813 .PMC 7773487 .PMID 33381848 .S2CID 229929774 . ^ Renz, Alina; Widerspick, Lina;Dräger, Andreas (2021)."Genome-Scale Metabolic Model of Infection with SARS-CoV-2 Mutants Confirms Guanylate Kinase as Robust Potential Antiviral Target" .Genes .12 (6): 796.doi :10.3390/genes12060796 .PMC 8225150 .PMID 34073716 .S2CID 235300463 . ^ Leonidou, Nantia; Renz, Alina; Mostolizadeh, Reihaneh;Dräger, Andreas (2023)."New workflow predicts drug targets against SARS-CoV-2 via metabolic changes in infected cells" .PLOS Computational Biology .19 (3) e1010903.doi :10.1371/journal.pcbi.1010903 .PMC 10035753 .PMID 36952396 .S2CID 257715107 .
International Academics People