 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | By mouth (throat lozenges) |
| ATC code |
|
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Metabolism | Oxidation,glucuronidation |
| Excretion | Via kidneys |
| Identifiers | |
| |
| CAS Number | |
| PubChemCID | |
| DrugBank | |
| ChemSpider |
|
| UNII | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.013.722 |
| Chemical and physical data | |
| Formula | C12H18O |
| Molar mass | 178.275 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 24 °C (75 °F) |
| |
| |
| (verify) | |
Amylmetacresol (AMC) is anantiseptic used to treatinfections of themouth andthroat. It is used as anactive pharmaceutical ingredient inStrepsils,Cēpacol,Gorpils,Cofsils andLorseptthroat lozenges, typically in combination withdichlorobenzyl alcohol, another antiseptic.[1][2]
The lozenges are used to treat sore throat and minor mouth and throat infections includingpharyngitis andgingivitis.[1][3]
A 2017meta-analysis found that the combination of AMC with dichlorobenzyl alcohol has a modest advantage over un-medicated lozenges regarding pain relief.[4][5]
No contraindications are known apart fromhypersensitivity to the substance.[1][2]
Amylmetacresol sometimes causes soreness of the tongue. Hypersensitivity reactions are very rare and show symptoms such asnausea ordyspepsia, although it is not entirely clear which side effects are caused by AMC and which by dichlorobenzyl alcohol or other ingredients of the lozenges.[1][3]
AMC has a low toxicity with anLD50 of 1500 mg/kg body weight (in rats).[3][6]
No cases of overdosing have been reported. It is not expected to cause symptoms other thangastrointestinal discomfort.[1][2]
No interactions with other drugs are known.[1][2]
Amylmetacresol is anantibacterial andantiviral substance. It alsoblocks sodium channels in a manner similar tolocal anaesthetics.[3] It has aRideal-Walker coefficient of 250.[6]
The substance is rapidly absorbed. It isoxidised to acarboxylic acid,glucuronidated, and quickly eliminated via the kidneys.[1][3]
AMC is a derivative ofm-cresol, with apentyl group attached to the sixth carbon atom. The pure substance melts at 24 °C (75 °F), and boils between 137 and 139 °C (279 and 282 °F) at a pressure of 6.7 kilopascals (50 mmHg). It is soluble in water,ethanol,acetone,diethylether, and oil.[6]
