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| Identifiers | |
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3D model (JSmol) | |
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| Properties | |
| C131H200N30O43S2 | |
| Molar mass | 2947.29 g/mol |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Amidorphin is anendogenous,C-terminallyamidated,opioidpeptide generated as acleavage product ofproenkephalin A in some mammalian species; in humans and most other species, the peptide is 1 residue longer and is not amidated. Amidorphin is widely distributed in themammalianbrain, with particularly high concentrations found in thestriatum, and outside of the brain inadrenal medulla andposterior pituitary.[1][2] The 26-residue peptide named amidorphin is found in several species including bovine (Bos taurus), sheep (Ovis aries), and pig (Sus scrofa). Humans and commonly studied lab animals (mice, rats) produce a 27-residue peptide that does not have an amidated C-terminal residue; this is due to the absence of a Gly in the precursor sequence and replacement with Ala, which is not a substrate for the amidating enzyme (Peptidyl-glycine alpha-amidating monooxygenase). The properties of the 27-residue peptide are presumably similar to those of amidorphin, although this has not been adequately tested.
In some brain areas, amidorphin is extensively further reduced into smaller fragments, such as the non-opioid peptideamidorphin-(8-26), or in humans, amidorphin-8-27. Cleavage of amidorphin into these smaller fragments releases theN-terminal[Met]-enkephalinsequence of amidorphin.[3]
