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Amidephrine

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
Amidephrine
Clinical data
Trade namesDricol, Fentrinol, Nalde
Other namesAmidefrine; MJ-1996; MJ-5190; 3-Methylsulfonamidyl-β-hydroxy-N-methylphenethylamine; 3-Methylsulfonamidyl-β-hydroxy-N-methyl-β-phenylethylamine
ATC code
  • None
Identifiers
  • (RS)-N-{3-[1-hydroxy-2-(methylamino)ethyl]phenyl}methanesulfonamide
CAS Number
PubChemCID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC10H16N2O3S
Molar mass244.31 g·mol−1
3D model (JSmol)
  • O=S(=O)(Nc1cc(ccc1)C(O)CNC)C
  • InChI=1S/C10H16N2O3S/c1-11-7-10(13)8-4-3-5-9(6-8)12-16(2,14)15/h3-6,10-13H,7H2,1-2H3 checkY
  • Key:ZHOWHMXTJFZXRB-UHFFFAOYSA-N checkY
  (verify)

Amidephrine (BANTooltip British Approved Name), oramidefrine, sold under the brand nameFentrinol among others, is aselectiveα1-adrenergic receptoragonist which is described as anadrenergic orsympathomimetic,vasoconstrictor, andtopicalnasal decongestant used to treatallergic rhinitis.[1][2][3][4][5] It is used as themesylatesalt, which has thegeneric namesamidefrine mesilate (INNTooltip International Nonproprietary Name) andamidephrine mesylate (USANTooltip United States Adopted Name).[2] The drug is asubstituted phenethylaminederivative and is also known as 3-methylsulfonamidyl-β-hydroxy-N-methylphenethylamine.[2][1][6] As of 2000, it remained marketed only inAustria.[3]

References

[edit]
  1. ^abElks J (2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 40.ISBN 978-1-4757-2085-3. Retrieved2024-08-31.
  2. ^abcMorton IK, Hall JM (2012).Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Netherlands. p. 13.ISBN 978-94-011-4439-1. Retrieved2024-08-31.
  3. ^abSchweizerischer Apotheker-Verein (2000).Index Nominum 2000: International Drug Directory. Medpharm Scientific Publishers. p. 39.ISBN 978-3-88763-075-1. Retrieved2024-08-31.
  4. ^"Amidephrine: Uses, Interactions, Mechanism of Action".DrugBank Online. 24 February 2021. Retrieved31 August 2024.
  5. ^MacLean MR, Thomson M, Hiley CR (June 1989)."Pressor effects of the alpha 2-adrenoceptor agonist B-HT 933 in anaesthetized and haemorrhagic rats: comparison with the haemodynamic effects of amidephrine".British Journal of Pharmacology.97 (2):419–432.doi:10.1111/j.1476-5381.1989.tb11969.x.PMC 1854522.PMID 2569342.
  6. ^"Amidephrine".PubChem. U.S. National Library of Medicine. Retrieved31 August 2024.
Decongestants and other nasal preparations (R01)
Topical
Sympathomimetics, plain
Antiallergic agents,
excluding corticosteroids
Corticosteroids
Other nasal preparations
Combination products
Systemic use:
Sympathomimetics
α1
Agonists
Antagonists
α2
Agonists
Antagonists
β
Agonists
Antagonists
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